Oxidative Coupling Reaction for the Determination of Lurasidone
- Авторы: Sudhir M.1, Nadh R.2, Manjunatha H.2
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Учреждения:
- Department of Chemistry, Sri Subbaraya and Narayana College
- GITAM University – Bengaluru Campus
- Выпуск: Том 74, № 6 (2019)
- Страницы: 528-533
- Раздел: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183221
- DOI: https://doi.org/10.1134/S1061934819060121
- ID: 183221
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Аннотация
A simple, sensitive, precise, accurate, highly reproducible and economical, visible spectrophotometric method for the determination lurasidone in bulk form was developed and validated. The method is based on the formation of an oxidative coupling product by the reaction of lurasidone with 3-methylbenzothiazolin-2-one hydrazone as a chromogenic reagent in presence of ferric chloride. The linear regression analysis data for the calibration plot showed good linear relationship within the concentration range of 0–100 μg/mL with a correlation coefficient (r) value of 0.9997. The limits of detection and quantitation are 0.6 and 1.7 µg/mL, respectively. The method was tested and validated according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (RSD < 2%).
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Об авторах
M. Sudhir
Department of Chemistry, Sri Subbaraya and Narayana College
Автор, ответственный за переписку.
Email: sudheer45147@yahoo.com
Индия, Narasaraopet, Andhra Pradesh, 522601
R. Nadh
GITAM University – Bengaluru Campus
Автор, ответственный за переписку.
Email: doctornadh@yahoo.co.in
Индия, Karnataka, 561203
H. Manjunatha
GITAM University – Bengaluru Campus
Email: doctornadh@yahoo.co.in
Индия, Karnataka, 561203