Novel Reactive Matrices for the Analysis of Alcohols by Matrix-Assisted Laser Desorption/Ioization Mass Spectrometry
- Авторы: Slyundina M.1, Borisov R.1, Zaikin V.1
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Учреждения:
- Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
- Выпуск: Том 73, № 14 (2018)
- Страницы: 1347-1352
- Раздел: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182928
- DOI: https://doi.org/10.1134/S1061934818140113
- ID: 182928
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Аннотация
A possibility of using a number of aromatic and heteroaromatic carboxylic acids and their halogen anhydrides as reactive matrix compounds for the analysis of alcohols of different structures by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been studied. It is shown that the acylation of alcohols with nicotinic and quinoline-6-carboxylic acid chlorides gives derivatives with high desorption/ionization efficiency under MALDI conditions, and that the free acids formed as a result of the hydrolysis of anhydrides act as matrix compounds. The proposed approach is tested on a number of aliphatic, alicyclic, and aromatic alcohols.
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Об авторах
M. Slyundina
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: borisov@ips.ac.ru
Россия, Moscow, 119991
R. Borisov
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: borisov@ips.ac.ru
Россия, Moscow, 119991
V. Zaikin
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: borisov@ips.ac.ru
Россия, Moscow, 119991