Separation of β-Blocker Enantiomers on Silica Modified with Gold Nanoparticles with Immobilized Macrocyclic Antibiotic Vancomicin
- Autores: Anan’eva I.1, Polyakova Y.1, Shapovalova E.1, Mazhuga A.1, Shpigun O.1
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Afiliações:
- Department of Chemistry
- Edição: Volume 73, Nº 2 (2018)
- Páginas: 152-159
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182968
- DOI: https://doi.org/10.1134/S1061934818020028
- ID: 182968
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Resumo
A new chiral sorbent based on mercaptosilica modified by gold nanoparticles, then treated by 3-mercaptopropionic acid and macrocyclic antibiotic vancomycin, was obtained. The enantioseparation of isomeric β-blockers (nadolol, atenolol, metoprolol, alprenolol, oxprenolol, and pindolol) by HPLC was studied on the synthesized sorbent. The effect of the composition of the mobile phase (nature and concentration of the organic solvent, concentration and pH of the buffer solution) on retention times of β-blocker enantiomers, selectivity of separation, and resolution of chromatographic peaks were studied. The best separation was achieved for pindolol and metoprolol. The procedure was used to determine the pindolol enantiomers in the preparation “Visken,” and metoprolol in the “Vazocardin” preparation.
Sobre autores
I. Anan’eva
Department of Chemistry
Autor responsável pela correspondência
Email: irishan@mail.ru
Rússia, Moscow, 119991
Ya. Polyakova
Department of Chemistry
Email: irishan@mail.ru
Rússia, Moscow, 119991
E. Shapovalova
Department of Chemistry
Email: irishan@mail.ru
Rússia, Moscow, 119991
A. Mazhuga
Department of Chemistry
Email: irishan@mail.ru
Rússia, Moscow, 119991
O. Shpigun
Department of Chemistry
Email: irishan@mail.ru
Rússia, Moscow, 119991