Derivatization of Ions under the Conditions of Surface Assisted Laser Desorption/Ionization
- Authors: Grechnikov A.A.1, Borodkov A.S.1, Nikiforov S.M.2
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Affiliations:
- Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
- Prokhorov Institute of General Physics, Russian Academy of Sciences
- Issue: Vol 74, No 3 (2019)
- Pages: 248-254
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183168
- DOI: https://doi.org/10.1134/S1061934819030055
- ID: 183168
Cite item
Abstract
A method for the chemical modification (derivatization) of ions obtained by surface assisted laser desorption/ionization (SALDI) is proposed. Derivatization is based on the interaction of desorbed ions with alcohol molecules. The method is simple, does not affect the duration of analysis and ensures the improvement of the analytical characteristics of the SALDI method, when analysis is carried out under the conditions of peak interference and strong fragmentation of analyte ions. The efficiency of the method is demonstrated in the determination of caffeine, pyrrolidine, and diphenhydramine under the conditions of atmospheric pressure sample application.
About the authors
A. A. Grechnikov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: grechnikov@geokhi.ru
Russian Federation, Moscow, 119991
A. S. Borodkov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: grechnikov@geokhi.ru
Russian Federation, Moscow, 119991
S. M. Nikiforov
Prokhorov Institute of General Physics, Russian Academy of Sciences
Email: grechnikov@geokhi.ru
Russian Federation, Moscow, 119991