A Molibdenum(VI)–Gallein–Diphenhydramine Ion Associate and Its Application to the Extraction-Photometric Determination of Diphenhydramine
- Authors: Mirzaeva K.A.1, Gamzaeva U.G.2
-
Affiliations:
- Faculty of Chemistry
- Dagestan State Medical University
- Issue: Vol 73, No 7 (2018)
- Pages: 661-666
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183090
- DOI: https://doi.org/10.1134/S1061934818070110
- ID: 183090
Cite item
Abstract
Optimum conditions for the formation and extraction of a slightly soluble ion associate of diphenhydramine with the anionic complex molibydenum–gallein were determined. The ternary complex was extracted with butanol at pH 4–7. In the presence of diphenhydramine, the color strength became stronger, which was manifested in the absorption spectra as hypsochromic and bathochromic shifts. Some physicochemical characteristics of the complex were determined, the specificity of the reaction with respect to diphenhydramine was studied, and the probable complexation scheme was proposed. It was found that the molybdenum–gallein–diphenhydramine complex forms at a component ratio of 1: 2: 2. A procedure for the extraction–photometric determination of diphenhydramine in injection solutions and tablets was developed (RSD = 15–20%). The linearity range of the calibration graph was 0.02–0.20 mg/mL.
About the authors
Kh. A. Mirzaeva
Faculty of Chemistry
Email: ulzana_g@mail.ru
Russian Federation, Makhachkala, 367001
U. G. Gamzaeva
Dagestan State Medical University
Author for correspondence.
Email: ulzana_g@mail.ru
Russian Federation, Makhachkala, 367000