Tryptamine: a Reactive Matrix for MALDI Mass Spectrometry
- Authors: Slyundina M.S.1, Polovkov N.Y.1, Borisov R.S.1,2, Zaikin V.G.1
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Affiliations:
- A. V. Topchiev Institute of Petrochemical Synthesis
- Russian Peoples Friendship University
- Issue: Vol 72, No 13 (2017)
- Pages: 1295-1299
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182711
- DOI: https://doi.org/10.1134/S106193481713010X
- ID: 182711
Cite item
Abstract
A possibility of using tryptamine as a reactive matrix for the analysis of non-polar carbonyl compounds by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been shown. Presence of a terminal primary amine group in the tryptamine molecule predetermines the formation of Schiff bases from aliphatic and alicyclic carbonyl compounds. No additional matrix compounds are necessary to register MALDI mass spectra, because the excess of the derivatization agent plays the role of a matrix. MALDI mass spectra demonstrate high efficiency of desorption/ionization of the derivatives. To discover reactive matrices, a set of aromatic primary amines (mainly substituted anilines) has been tested, but they have not demonstrated matrix properties.
About the authors
M. S. Slyundina
A. V. Topchiev Institute of Petrochemical Synthesis
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119991
N. Yu. Polovkov
A. V. Topchiev Institute of Petrochemical Synthesis
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119991
R. S. Borisov
A. V. Topchiev Institute of Petrochemical Synthesis; Russian Peoples Friendship University
Author for correspondence.
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119991; Moscow, 117198
V. G. Zaikin
A. V. Topchiev Institute of Petrochemical Synthesis
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119991
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