A comparative protein profiling of lymphocytes from blood of patients with chronic lymphoid leukemia by high-resolution mass-spectrometry in search of new markers for heterogeneity and disease prognosis
- Authors: Glazyrin Y.E.1, Komarova M.A.1, Bakhtina V.I.1,2, Silacheva M.V.1, Demko I.V.1,2, Zamay A.S.1, Zamay T.N.1
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Affiliations:
- Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
- Krasnoyarsk Regional Clinical Hospital
- Issue: Vol 71, No 13 (2016)
- Pages: 1242-1250
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182216
- DOI: https://doi.org/10.1134/S1061934816130062
- ID: 182216
Cite item
Abstract
To find new markers of chronic lymphoid leukemia heterogeneity, a comparison of the proteomic profiles of pathologic and healthy lymphocytes from blood was carried out by high-resolution mass spectrometry and label-free quantitative analysis. A list of the most typical proteins for the two groups was obtained. The differences in the proteomic profiles within the pathologic group, which were consistent with the heterogeneity of clinical background, were found. Two subsets within the area of the pathologic cells were formed using statistical analysis; the list of characteristic proteins for each subset was obtained.
About the authors
Yu. E. Glazyrin
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Author for correspondence.
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022
M. A. Komarova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022
V. I. Bakhtina
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky; Krasnoyarsk Regional Clinical Hospital
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022; ul. Partizana Zheleznyaka 3a, Krasnoyarsk, Krasnoyarsk krai, 660022
M. V. Silacheva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022
I. V. Demko
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky; Krasnoyarsk Regional Clinical Hospital
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022; ul. Partizana Zheleznyaka 3a, Krasnoyarsk, Krasnoyarsk krai, 660022
A. S. Zamay
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022
T. N. Zamay
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: yury.glazyrin@gmail.com
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022