Silica-based mesoporous organic-inorganic nano-hybrid: a novel electroceramic nanomaterial for electroanalytical determination of selected cardiovascular drugs in human serum
- Authors: Hasanzadeh M.1, Pournaghi-Azar M.H.2, Shadjou N.3,4, Jouyban A.5
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Affiliations:
- Drug Applied Research Center
- Electroanalytical Chemistry Laboratory
- Department of Nanochemistry
- Department of Chemistry
- Pharmaceutical Analysis Research Center and Faculty of Pharmacy
- Issue: Vol 71, No 4 (2016)
- Pages: 386-395
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181635
- DOI: https://doi.org/10.1134/S106193481602009X
- ID: 181635
Cite item
Abstract
Magnetic mesoporous silica was used for electrode modification and electro-oxidation of some cardiovascular drugs. The modified electrode was applied for detection of cardiovascular drugs using cyclic voltammetry, chronoamperometry, and differential pulse voltammetry. The modified electrode shows many advantages as an electrochemical sensor such as simple preparation method without using any specific electron transfer mediator or specific reagent, high sensitivity, excellent activity, short response time, long term stability and remarkable antifouling property toward for cardiovascular drugs and its oxidation product. Finally, the applicability of the sensor for determination of the selected drugs in human serum samples has been successfully demonstrated.
About the authors
Mohammad Hasanzadeh
Drug Applied Research Center
Email: info@pleiadesonline.com
Iran, Islamic Republic of, Tabriz, 51664
Mohammad Hossein Pournaghi-Azar
Electroanalytical Chemistry Laboratory
Email: info@pleiadesonline.com
Iran, Islamic Republic of, Tabriz
Nasrin Shadjou
Department of Nanochemistry; Department of Chemistry
Email: info@pleiadesonline.com
Iran, Islamic Republic of, Urmia; Urmia
Abolghasem Jouyban
Pharmaceutical Analysis Research Center and Faculty of Pharmacy
Email: info@pleiadesonline.com
Iran, Islamic Republic of, Urmia