Methodology of analysis of unseparated mixtures: Interval estimates of the total concentration of similar analytes
- Authors: Vershinin V.I.1, Isachenko N.A.1, Brilenok N.S.1
-
Affiliations:
- Dostoevsky Omsk State University
- Issue: Vol 71, No 4 (2016)
- Pages: 351-358
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181613
- DOI: https://doi.org/10.1134/S1061934816040080
- ID: 181613
Cite item
Abstract
Determination of the total concentration (cΣ) of similar analytes recalculated to a standard substance Xst is a widely used but metrologically incorrect procedure leading to a high uncertainty of the results of analysis. An algorithm is proposed for the interval estimation of cΣ without recalculating to the concentration of Xst. The algorithm takes into account different sensitivities of the determination of analytes of the studied type. No information on the nature and ratio of analytes in the sample is used. The width of the range of possible values of cΣ objectively characterizes the systematic component of the error, it is independent of the choice of Xst, exceeds the width of traditional confidence intervals, and becomes zero at equal sensitivities of the determination of all analytes in a group. The accuracy of interval estimates is supported by the analysis of model mixtures of different types using several methods of measuring the total signal.
About the authors
V. I. Vershinin
Dostoevsky Omsk State University
Author for correspondence.
Email: vyvershinin@yandex.ru
Russian Federation, pr. Mira 55-A, Omsk, 644077
N. A. Isachenko
Dostoevsky Omsk State University
Email: vyvershinin@yandex.ru
Russian Federation, pr. Mira 55-A, Omsk, 644077
N. S. Brilenok
Dostoevsky Omsk State University
Email: vyvershinin@yandex.ru
Russian Federation, pr. Mira 55-A, Omsk, 644077