Gas-chromatographic determination of trace amounts of tetrodotoxin in water, drugs, and blood plasma
- Authors: Stan’kov I.N.1, Kondrat’ev V.B.1, Derevyagina I.D.1, Morozova O.T.1, Selivanova V.I.1, Semchenko F.M.2, Rufanov K.A.2, Dvoretskaya S.I.1
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Affiliations:
- State Research Institute of Organic Chemistry and Technology
- State Pharmaceutical Plant
- Issue: Vol 71, No 3 (2016)
- Pages: 289-296
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181571
- DOI: https://doi.org/10.1134/S1061934816030138
- ID: 181571
Cite item
Abstract
A method has been developed for the determination of tetrodotoxin in water, blood plasma, and drugs at a level of 0.05—1.0 µg/mL. The method is based on the hydrolytic decomposition of tetrodotoxin by a sodium hydroxide solution, extraction of 2-amino-6-hydroxymethyl-8-hydroxyquinazoline using liquid–liquid extraction, preparation of its derivative by reaction with N,O-bis(trimethylsilyl)trifluroacetamide, and the determination of the derivative by gas–liquid chromatography with a mass-spectrometric detector.
About the authors
I. N. Stan’kov
State Research Institute of Organic Chemistry and Technology
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024
V. B. Kondrat’ev
State Research Institute of Organic Chemistry and Technology
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024
I. D. Derevyagina
State Research Institute of Organic Chemistry and Technology
Author for correspondence.
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024
O. T. Morozova
State Research Institute of Organic Chemistry and Technology
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024
V. I. Selivanova
State Research Institute of Organic Chemistry and Technology
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024
F. M. Semchenko
State Pharmaceutical Plant
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23Moscow, 111024
K. A. Rufanov
State Pharmaceutical Plant
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23Moscow, 111024
S. I. Dvoretskaya
State Research Institute of Organic Chemistry and Technology
Email: irinagosnii@gmail.com
Russian Federation, sh. Entuziastov 23, Moscow, 111024