Email this article Some indices of neoplastic angiogenesis in tissues of rectal tumors with various morphological structures
- Authors: Kit O.I1, Frantsiyants E.M1, Nikipelova E.A1, Komarova E.F.1
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Affiliations:
- Rostov Research Institute of Oncology
- Issue: Vol 20, No 2 (2015)
- Pages: 12-18
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40108
- DOI: https://doi.org/10.17816/onco40108
- ID: 40108
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Abstract
The development and growth of the neoplasm is carried out directly by the ability to produce angiogenic factors that stimulate neovascularization. In the tumors of the rectum of various origins (primary adenocarcinoma of stage III (n = 73) and polyps (n = 35): tubular adenoma, villous adenoma, tubular-villous adenoma) the performance of tissue fibrinolytic system and the level of growth factors was studied. A common feature in the tissue of colorectal cancer and polyps is the high content of VEGF-A, VEGF-R and TGF-β1, as well as the increased formation of plasmin, which indicates an increase in angiogenesis and cell proliferation processes violation tissue. Expression of growth factors and functioning of the fibrinolytic system in the case of malignant’s transformation is in better interaction and mutual influence and has a greater number of correlations. In tissue polyps indicators of studiedfactors generally occupy an intermediate position between the cancer and the intact tissue, which shows the possible ways of their cancer’s transformation.
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##article.viewOnOriginalSite##About the authors
O. I Kit
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
E. M Frantsiyants
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
E. A Nikipelova
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
Ekaterina F. Komarova
Rostov Research Institute of Oncology
Email: super.gormon@ya.ru
PhD, Doctor of Biological Sciences 344037, Rostov-on-Don, Russia
References
- Бабкина И.В., Осипов Д.А., Соловьев Ю.Н., Булычева И.В., Мачак Г.Н., Алиев М.Д., Кушлинский Н.Е. Эндостатин, плацентарный фактор роста и факторы роста фибробластов первого и второго типа в сыворотке крови больных первичными опухолями костей. Бюллетень экспериментальной биологии и медицины. 2009; 148 (8): 218-22.
- Xudong Tang, Qunzhou Zhang, Shihong Shi, YunYen, Xiangyong Li, Yuefei Zhang et al. Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1a/VEGF signaling pathways in human breast cancer cells. Int. J. Cancer. 2010; 126 (1): 90-103.
- Жуков Н.В. Ангиогенез как фактор метастазирования и мишень для противоопухолевой терапии. Вопросы гематологии, онкологии и иммунопатологии в педиатрии. 2009; 8 (4): 27-33.
- Runkel S., Hunter N., Milas L. An intradermal assay for quantification and kinetics studies of tumor angiogenesis in mice. Radiat Res. 1991; 126 (2): 237-43.
- Bendardaf Riyad, Buhmeida Abdelbaset, Hilska Marja et al. VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival. Anticancer Res. 2008; 28 (68): 3865-70.
- Be§ta§ R., Kaplan M.A., I§ikdogan A. The correlation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma Hepatogastmentemlogy. 2014; 61(130): 267-71.
- Hanrahan V., Currie M.L., Cunningham S.P. et al. The angiogenic switch for vascular endothelial cell growth factor (VEGF)- A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J. Pathol. 2003; 200 (2): 183-94.
- Парфенова Е.В., Плеханова О.С., Ткачук В.А. Система активаторов плазминогена в ремоделировании сосудов и ангиогенезе. Биохимия. 2002; 67 (1): 139-56.
- Mostefai H.A., Andriantsitohaina R., Martinez M.C. Plasma membrane microparticles in angiogenesis: role in ischemic diseases and in cancer. Physiol. Res. 2008; 57 (3): 311-20.
- Матякин Е.Г., Герштейн Е.С., Кушлинский Н.Е. н др. Активаторы плазминогена урокиназного и тканевого типов и их ингибитор PAI-1 в опухолях больных раком слизистой оболочки полости рта: взаимосвязь с основными клинико-морфологическими факторами. Российский биотерапевтический журнал. 2009; 4: 29-32.
- Воротников И.К., Тулеуова А.А., Мамедов У.Р. н др. Содержание активатора плазминогена урокиназного типа в цитозоле опухолей молочной железы. Вопросы биологической, медицинской и фармацевтической химии. 2010; 6: 28-31.
- Франциянц Е.М., Моисеенко Т.И., Кошелева О.Н., Адамян М.Л. Состояние некоторых компонентов фибринолитической системы ткани эндометрия при синхронном развитии рака эндометрия и миомы матки. Паллиативная медицина и реабилитация. 2012; 4: 43-6.
- Folkman J. Angiogenesis. Annu. Rev. Med. 2006; 57: 1-18.
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