Email this article Some indices of neoplastic angiogenesis in tissues of rectal tumors with various morphological structures
- Authors: Kit O.I1, Frantsiyants E.M1, Nikipelova E.A1, Komarova E.F.1
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Affiliations:
- Rostov Research Institute of Oncology
- Issue: Vol 20, No 2 (2015)
- Pages: 12-18
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40108
- DOI: https://doi.org/10.17816/onco40108
- ID: 40108
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Abstract
The development and growth of the neoplasm is carried out directly by the ability to produce angiogenic factors that stimulate neovascularization. In the tumors of the rectum of various origins (primary adenocarcinoma of stage III (n = 73) and polyps (n = 35): tubular adenoma, villous adenoma, tubular-villous adenoma) the performance of tissue fibrinolytic system and the level of growth factors was studied. A common feature in the tissue of colorectal cancer and polyps is the high content of VEGF-A, VEGF-R and TGF-β1, as well as the increased formation of plasmin, which indicates an increase in angiogenesis and cell proliferation processes violation tissue. Expression of growth factors and functioning of the fibrinolytic system in the case of malignant’s transformation is in better interaction and mutual influence and has a greater number of correlations. In tissue polyps indicators of studiedfactors generally occupy an intermediate position between the cancer and the intact tissue, which shows the possible ways of their cancer’s transformation.
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##article.viewOnOriginalSite##About the authors
O. I Kit
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
E. M Frantsiyants
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
E. A Nikipelova
Rostov Research Institute of Oncology344037, Rostov-on-Don, Russia
Ekaterina F. Komarova
Rostov Research Institute of Oncology
Email: super.gormon@ya.ru
PhD, Doctor of Biological Sciences 344037, Rostov-on-Don, Russia
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