Email this article Malignant neoplasms of the respiratory tract and thoracic organs in the remote period in males of Altai krai affected by first nuclear test at Semipalatinsk test site
- Authors: Kovrigin A.O.1, Kolyado I.B.2, Lubennikov V.A.3, Vikhlyanov I.V.3, Lazarev A.F.4, Shoikhet Y.N.4
-
Affiliations:
- Institute for Water and Environmental Problems, Siberian Branch of the Russian Academy of Sciences
- Institute of Regional Medico-Ecological Problems
- Аltai Regional Oncologic Dispensary
- Altai State Medical University
- Issue: Vol 27, No 4 (2022)
- Pages: 165-170
- Section: Original Study Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/249477
- DOI: https://doi.org/10.17816/onco568565
- ID: 249477
Cite item
Open Access
Access granted
Subscription Access
Abstract
BACKGROUND: The study of remote effects of radiation exposure on tumor-related morbidity in population remains a matter of great social significance in Altai Krai.
AIM: To investigate the incidence rate for malignant neoplasms of respiratory tract and thoracic organs in the remote period in the male population born in 1932–1949 and located in the zone of influence of the first nuclear test.
METHODS: This retrospective cohort study was based on the analysis of anonymized data and surgical records on morphologically verified cases of primary malignant neoplasms in a male cohort for the period from 2007 to 2016. In this paper, we studied a cohort fixed by the date of the first nuclear test, with a total of 6383 male individuals. The main (exposed) cohort included 2291 men, while the control (non-exposed) cohort included 4092 men who lived in rural communities of the region that were not affected during the first nuclear test. The cohort included 156 cases of morphologically verified diagnosis of primary malignant neoplasms of the respiratory tract and thoracic organs (codes C30–C39 according to the International Classification of Diseases). Person-time incidence rate (PtR), standard error (mPtR) and confidence intervals (95% CI) were calculated. The incidence of respiratory and thoracic malignant neoplasms, structure and relative risk (RR) were assessed. Statistical processing of the data was performed using licensed Microsoft Office 2016 software.
RESULTS: The number of person-years spent at risk for respiratory and thoracic malignancies in the male population in the main cohort was 16 731 person-years, and in the control cohort — 30 747 person-years. In the main cohort, PtR was 436.32×105 person-years, with an mPtR of 51.07 and 95% CI of 334.18–538.45; in the control cohort the PtR was 269.95×105 person-years with an mPtR of 29.63 and 95% CI of 210.68–329.21. The leading localizations of malignant neoplasms of the respiratory and thoracic organs in men in the main and control cohorts were bronchial and lung malignancies and laryngeal malignancies.
CONCLUSIONS: An increased relative risk of respiratory and thoracic malignant neoplasms manifesting in the remote period in the male population born and living in rural areas of Altai Krai during the first nuclear test conducted at the Semipalatinsk test site was revealed: RR=1.616, 95% CI 1.180–2.214, with the standard error of relative risk equal to 0.160.
Full Text
##article.viewOnOriginalSite##About the authors
Anton O. Kovrigin
Institute for Water and Environmental Problems, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: anton-kovrigin@yandex.ru
ORCID iD: 0000-0002-0214-0192
SPIN-code: 2870-3906
MD
Russian Federation, BarnaulIgor B. Kolyado
Institute of Regional Medico-Ecological Problems
Email: irmep@yandex.ru
ORCID iD: 0000-0002-7531-4675
SPIN-code: 2068-4904
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, BarnaulVladimir A. Lubennikov
Аltai Regional Oncologic Dispensary
Email: vladimir-lubennikov@mail.ru
ORCID iD: 0000-0002-0407-5435
SPIN-code: 5747-6503
MD, Cand. Sci. (Med.)
Russian Federation, BarnaulIgor V. Vikhlyanov
Аltai Regional Oncologic Dispensary
Email: evp59@bk.ru
ORCID iD: 0000-0003-3290-7187
MD, Dr. Sci. (Med.)
Russian Federation, BarnaulAlexandr F. Lazarev
Altai State Medical University
Email: lazarev@akzs.ru
ORCID iD: 0000-0003-1080-5294
SPIN-code: 1161-8387
MD, Dr. Sci. (Med.), Professor
Russian Federation, BarnaulYakov N. Shoikhet
Altai State Medical University
Email: starok100@mail.ru
ORCID iD: 0000-0002-5253-4325
SPIN-code: 6379-3517
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, BarnaulReferences
- Yadernye ispytaniya SSSR. Moscow: IzdAT; 1997. (In Russ).
- Shoikhet YaN, Kiselev VI, Loborev VM, et al. Nuclear test on August 29, 1949. Radiation effect on the population of the Altai Territory. Barnaul: NII RMEP; 1997. (In Russ).
- Shoikhet YaN, Kiselev VI, Loborev VM, et al. Radiation impact on the population of the Altai Territory of nuclear tests at the Semipalatinsk test site. Barnaul: NII RMEP; 1999. (In Russ).
- O sostoyanii i ob okhrane okruzhayushchei sredy v Altaiskom krae v 2021 godu. State report. Barnaul; 2022. (In Russ).
- O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Altaiskom krae v 2022 godu. State report. Barnaul; 2023. (In Russ).
- Shoikhet YaN, Kiselev VI, Kolyado IB, Algazin AI. Medical Consequences of Radiation on the Trail of a Nuclear Explosion. Barnaul: Siberian Branch of the Russian Academy of Sciences; 2002. (In Russ).
- Shoigu SK, editor. Posledstviya radiatsionnogo vozdeistviya yadernykh ispytanii naseleniya Altaiskogo kraya i mery po ego sotsial’noi zashchite. Barnaul: AzBuka; 2003. (In Russ).
- Pisareva LF, Boyarkina AP, Takhauov RM, Karpov AB. Osobennosti onkologicheskoi zabolevaemosti naseleniya Sibiri i Dal’nego Vostoka. Tomsk: Tomsk; 2001. (In Russ).
- Kolyado IB, Plugin SV, Tribunskii SI. Aftereffects of the Impact of the Radiation Exposure on the Territory and the Population of the Altai Krai. Hygiene and sanitation. 2018;97(7):609–617. (In Russ). doi: 10.18821/0016-9900-2018-97-7-609-617
- Shoikhet YaN, Lazarev AF, Аgeev АG. Lung cancer in the Altai region. Barnaul: AzBuka; 2006. (In Russ).
- Postanovlenie Soveta Ministrov — Pravitel’stva Rossiiskoi Federatsii № 1160 ot 16.11.1993. «O Gosudarstvennoi programme po reabilitatsii naseleniya i sotsial’no-ekonomicheskomu razvitiyu raionov Altaiskogo kraya, podvergshikhsya radiatsionnomu vozdeistviyu v rezul’tate yadernykh ispytanii na Semipalatinskom poligone». (In Russ).
- Ahlbom A, Norell S. Introduction to modern epidemiology. Tallinn; 1996. (In Russ).
- Breslow NE, Day NE. Statistical Methods in Cancer Research. Volume II — The design and analysis of cohort studies. Lyon: IARC Scientific Publications (82); 1987.
- Centers for Disease Control and Prevention (U.S.), Office of Workforce and Career Development. Principles of epidemiology in public health practice. An introduction to applied epidemiology and biostatistics. United States; 2012.
- Otdel’nova KA. Opredelenie neobkhodimogo chisla nablyudenii v sotsial’no-gigienicheskikh issledovaniyakh. Sb. trudov 2-go MMI. 1980;150(6):18–22. (In Russ).
- Narkevich AN, Vinogradov KA. Methods for determining the minimum required sample size in medical research. Social’nye aspekty zdorov’a naselenia (Social aspects of population health). 2019;65(6):10. (In Russ). doi: 10.21045/2071-5021-2019-65-6-10
- Dronov SV. Metody i zadachi mnogomernoi statistiki. Barnaul: AltGU; 2015. (In Russ).
- Rasporyazhenie Pravitel’stva RF ot 08.02.2002 № 156-r «O perechne naselennykh punktov Altaiskogo kraya, podvergshikhsya radiatsionnomu vozdeistviyu vsledstvie yadernykh ispytanii na Semipalatinskom poligone». (In Russ).
Supplementary files
