ANTI-TUMOR AND IMMUNOMODULATING EFFECTS OF RECOMBINANT HUMAN TUMOR NECROSIS FACTOR ALPHA IN A DELIVERY SYSTEMIN B16-F10 MELANOMA MICE
- 作者: Sysoeva G.1, Ryabchikova E.2, Gamaley S.1, Lebedev L.1, Volosnikova E.1, Danilenko E.1
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隶属关系:
- Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
- Institute of Chemical Biology and Fundamental Medicine SB RAS
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 575-577
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120306
- DOI: https://doi.org/10.31857/S102872210006979-1
- ID: 120306
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详细
It was established that recombinant human tumor necrosis factor alpha in a delivery system has pronounced antitumor and immunomodulating effects in murine B16-F10 melanoma model. The preparation significantly inhibited the growth of experimental tumor (TGI 60%), increased tumor infiltration by immune system cells (CD3+, CD11b+) and increased the activity of immunocompetent cells mediating antitumor response.
作者简介
G. Sysoeva
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
编辑信件的主要联系方式.
Email: sysoeva_gm@vector.nsc.ru
SRF, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Ryabchikova
Institute of Chemical Biology and Fundamental Medicine SB RAS
Email: fake@neicon.ru
Institute of Chemical Biology and Fundamental Medicine,
Berdsk, Novosibirsk Region
俄罗斯联邦S. Gamaley
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Head of Department of Biological Research,
Berdsk, Novosibirsk Region
俄罗斯联邦L. Lebedev
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Dr. habil., Head of the laboratory of Nucleic Acids and Recombinant Proteins,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Volosnikova
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, Head of Laboratory of Obtaining and Analysis of Bio substances,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Danilenko
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, director, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
俄罗斯联邦参考
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