ANTI-TUMOR AND IMMUNOMODULATING EFFECTS OF RECOMBINANT HUMAN TUMOR NECROSIS FACTOR ALPHA IN A DELIVERY SYSTEMIN B16-F10 MELANOMA MICE
- 作者: Sysoeva G.1, Ryabchikova E.2, Gamaley S.1, Lebedev L.1, Volosnikova E.1, Danilenko E.1
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隶属关系:
- Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
- Institute of Chemical Biology and Fundamental Medicine SB RAS
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 575-577
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120306
- DOI: https://doi.org/10.31857/S102872210006979-1
- ID: 120306
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全文:
详细
It was established that recombinant human tumor necrosis factor alpha in a delivery system has pronounced antitumor and immunomodulating effects in murine B16-F10 melanoma model. The preparation significantly inhibited the growth of experimental tumor (TGI 60%), increased tumor infiltration by immune system cells (CD3+, CD11b+) and increased the activity of immunocompetent cells mediating antitumor response.
作者简介
G. Sysoeva
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
编辑信件的主要联系方式.
Email: sysoeva_gm@vector.nsc.ru
SRF, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Ryabchikova
Institute of Chemical Biology and Fundamental Medicine SB RAS
Email: fake@neicon.ru
Institute of Chemical Biology and Fundamental Medicine,
Berdsk, Novosibirsk Region
俄罗斯联邦S. Gamaley
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Head of Department of Biological Research,
Berdsk, Novosibirsk Region
俄罗斯联邦L. Lebedev
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Dr. habil., Head of the laboratory of Nucleic Acids and Recombinant Proteins,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Volosnikova
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, Head of Laboratory of Obtaining and Analysis of Bio substances,
Berdsk, Novosibirsk Region
俄罗斯联邦E. Danilenko
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, director, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
俄罗斯联邦参考
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- Deryagina V. P., Ryzhova N. I., Krivosheeva L. V., Saluchinskay L. A., Golubeva I. S., Reutov V. P. Functional activity of effector cells of innate immunity in tumor bearing mice. Modern science, 2016, № 11, 69–76.
