ANTIGENPRESENTAL FUNCTION OF B-CELLS IN PATIENTS WITH REMITTING MULTIPLE SCLEROSIS
- 作者: Sursyakova N.1, Kuklina E.2, Baydina T.1
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隶属关系:
- Federal State Educational Institution of Higher Education “Perm State Medical University named after Academician E. A. Vagner" of the Ministry of Health of the Russian Federation
- Federal State Institution of Science Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
- 期: 卷 20, 编号 3 (2017)
- 页面: 519-521
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119910
- ID: 119910
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详细
The antigen-presenting function of B-lymphocytes in patients with a remitting form of multiple sclerosis was studied. It was found that B cells in the presentation of different antigens have a different ability to induce differentiation of naive T cells in Th17 and Treg. A new mechanism for activating the differentiation of naive T cells in Th17 in the presentation of autoantigens with B cells in multiple sclerosis has been suggested.
作者简介
N. Sursyakova
Federal State Educational Institution of Higher Education “Perm State Medical University named after Academician E. A. Vagner" of the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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E. Kuklina
Federal State Institution of Science Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
俄罗斯联邦
T. Baydina
Federal State Educational Institution of Higher Education “Perm State Medical University named after Academician E. A. Vagner" of the Ministry of Health of the Russian Federation
Email: noemail@neicon.ru
俄罗斯联邦
参考
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- Molnarfi N., Schulze-Topphoff U., Weber M.S., Patarroyo J.C., Prod’homme T., Varrin-Doyer M., Shetty A., Linington C., Slavin A.J., Hidalgo J., Jenne D.E., Wekerle H., Sobel R.A., Bernard C.C., Shlomchik M.J., Zamvil S.S. MHC class II-depen-dent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med. 2013 Dec 16;210(13): 2921-37.
- Dalai S.K., Mirshahidi S,. Morrot A., Zavala F., Sa-degh-Nasseri S. Anergy in Memory CD4+ T Cells Is Induced by B Cells,. Journal of immunology 2008;181(5):3221-3231.
- Sara Morlacchi, Cristiana Soldani, Antonella Viola and Adelaida Sarukhan. Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion. Blood 2011 118:984-991.
- Ellis J.S, Braley-Mullen H. Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases. J. Clin. Med. 2017, 6(2), 13.
