Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis

封面

如何引用文章

全文:

详细

Children of 6–17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 74 with active arthritis and 14 with remission were treated with disease modifying therapy, 12 children with persistent remission and 32 apparently healthy children were without medications. The amount of CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4–СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg and СD3+СD4+СD25+СD127+ were investigated by fl ow cytometry. In all children with juvenile idiopathic arthritis the number regulatory T-cells (CD3+CD4+CD25+CD127low/neg) and double-positive lymphocytes (СD3+СD4+СD8+) was decreased. The amount of NKT (СD3+СD16/56+) in patients with active arthritis and with remission was too decreased.

作者简介

I. Pashnina

Regional Children’s Clinical Hospital № 1; Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.

编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦

参考

  1. Hayward K., Wallace C. A. Recent developments in antirheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis. Arthritis Research & Therapy 2009, 11, 216–227.
  2. Алексеева Е. И., Литвицкий П. Ф. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения, под ред. А. А. Баранова. М.: ВЕДИ. 2007. 368 с. [Alekseeva E. I., Litvitskiy P. F. Juvenile rheumatoid arthritis: etiology, pathogenesis, clinic, algorithms of diagnostics and treatment. Ed. A. A. Baranov. Moskow: VEDI. 2007. 368].
  3. Rypdal V., Arnstad E. D., Aalto K., Berntson L., Ekelund M., Fasth A., Glerup M., Herlin T., Nielsen S., Peltoniemi S., Zak M., Rygg M., Rypdal M., Nordal E. Predicting unfavorable long-term outcome in juvenile idiopathic arthritis: results from the Nordic cohort study. Arthritis Research & Therapy 2018, 20:91.
  4. Ревматология: Клинические рекомендации / Под ред. Л. Насонова. М.: ГЭОТАР-Медиа. 2010. 752 c. [Rheumatology: Clinical recomendation. Ed. L. Nasonov. Moscow: GEOTAR-Media, 2010, 752].
  5. Tosato F., Bucciol G., Pantano G., Putti M. C., Sanzari M. C., Basso G., Plebani M. Lymphocytes Subsets Reference Values in Childhood. Cytometry Part A 2015, 87A, 81–85.
  6. Odum N., Morling N., Platz P., Hofmann B., Ryder L. P., Heilmann C., Pedersen F. K., Nielsen L. P., Friis J., Svejgaard A. Increased prevalence of late stage T cell activation antigen (VLA-1) in active juvenile chronic arthritis. Annals of the Rheumatic Diseases 1987, 46, 846–852.
  7. Bendersky A., Marcu-Malina V., Berkun Y., Gerstein M., Nagar M., Goldstein I., Padeh S., Bank I. Cellular Interactions of Synovial Fluid ??T Cells in Juvenile Idiopathic Arthritis. The Journal of Immunology 2012, 188, 4349–4359.
  8. Berkun Y., Bendersky A., Gerstein M., Goldstein I., Padeh S., Bank I. T cells in Juvenile Idiopathic Arthritis: Higher Percentages of Synovial V?1+ and V?9+ T Cell Subsets Are Associated with Milder Disease. J. Rheumatol. 2011, 38, 1123–1129.
  9. Hunter P. J., Nistala K., Jina N., Eddaoudi A., Thomson W., Hubank M., Wedderburn L. R. Biologic Predictors of Extension of Oligoarticular Juvenile Idiopathic Arthritis as Determined From Synovial Fluid Cellular Composition and Gene Expression. Arthritis & Rheumatism 2010, 62, 3, 896–907.
  10. Nascimbeni M., Shin E. C., Chiriboga L., Kleiner D. E., Rehermann B. Peripheral CD4(+)CD8(+) T cells are diff erentiated eff ector memory cells with antiviral functions. Blood 2004, 104, 478–486.
  11. Кудрявцев И. В., Захарова Г. А., Гапонова Т. В., Горчакова М. В. Исследование основных субпопуляций Т-хелперов и цитотоксических Т-клеток при ревматоидном артрите. Российский иммунологический журнал 2014, 8 (17), 2 (1), 89–92. [Kudriavcev I. V., Zaharova H. A., Gaponova T. V, Gorchacova M. V. Research of the main subpopulations of Т-helpers and cytotoxic T-cells at rheumatoid arthritis. Russian Journal of Immunology 2014, 8 (17), 2 (1), 89–92].
  12. Armengol M. P., L. Sabater M., Fernandez Ruiz M., Alonso N., Otero M. J., Martinez-Caceres E., Jaraquemada D., Pujol-Borrell R. Infl ux of recent thymic emigrants into autoimmune thyroid disease glands in humans. Clinical and Experimental Immunology 2008, 153, 338–350.
  13. Parel Y., Aurrand-Lions M., Scheja A., Dayer J. M., Roosnek E., Chizzolini C. Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis. Arthritis. Rheum. 2007, 56, 3459– 3467.
  14. Cho Y.-N., Kee S.-J., Lee S.-J., Seo S.-R., Kim T.-J., Lee S.-S., Kim M.-S., Lee W.-W., Yoo D.-H., Kim N., Park Y.-W. Numerical and functional defi ciencies of natural killer T cells in systemic lupus erythematosus: their defi ciency related to disease activity. Rheumatology 2011, 50, 1054–1063.
  15. Linsen L., Somers V, Stinissen P. Immunoregulation of autoimmunity by natural killer T cells. Hum. Immunol. 2005, 66 (12), 1193–202.
  16. McKee S. J., Mattarollo S. R., Leggatt G. R. Immunosuppressive roles of natural killer T (NKT) cells in the skin. J. Leukoc. Biol. 2014, 9, 49–54.
  17. Sakaguchi S. Regulatory T Cells: History and Perspective. Methods in Molecular Biology 2011, 707, 3–17.
  18. Sempere-Ortells J.M., Perez-Garcia V., Marin-Alberca G., Peris-Pertusa A., Benito J. M., Marco F. M., Zubcoff J. J., Navarro-Blasco F. J. Quantifi cation and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28. Autoimmunity 2009, 42 (8), 636–645.
  19. Tang T.-T., Song Y., Ding Y.-J., Liao Y.-H., Yu X., Du R., Xiao H., Yuan J., Zhou Z.-H., Liao M.-Y., Yao R., Jevallee H., Shi G.-P., Cheng X. Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis. J. Lipid Res. 2011, 52, 1023–1032.
  20. Kleer I. M., Wedderburn L. R., Taams L. S., Patel A., Varsani H., Klein M., de Jager W., Pugayung G., Giannoni F., R? kers G., Albani S., Kuis W., Prakken B. CD4+ CD25bright regulatory T cells actively regulate infl ammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. 2004, 172, 6435–6443.
  21. Wei C.-M., Lee J.-H., Wang L.-C., Yang Y.-H., Chang L.-Y., Chiang B.-L. Frequency and phenotypic analysis of CD4+ CD25+ regulatory T cells in children with juvenile idiopathic arthritis. Journal. of microbiology, immunology and infection 2008, 41, 1, 78–87.

版权所有 © Pashnina I..., 2018

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
##common.cookie##