IMBALANCE OF CHEMOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF MALE INFERTILITY

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The aim of study was to evaluate the role of chemokines and growth factors in the development of idiopathic infertility. In serum and seminal plasma of the infertile men the deficit and the imbalance of stromal cell factors SDF-1α and transforming growth factor TGFβ, spermatogenesis and modulators of the immune response in the reproductive system are identified. Possible mechanisms for the negative impact of the identified features of the cytokine profile on the fertilizing capacity of sperm were discussed.

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E. Galimova

Bashkir State Medial University

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A. Gaysina

Bashkir State Medial University

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O. Travnikov

Bashkir State Medial University

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K. Bulygin

Bashkir State Medial University

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G. Akhmadullina

Bashkir State Medial University

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S. Galimov

Bashkir State Medial University

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参考

  1. Kashanian J., Brannigan R. Male Infertility. Robert E Brannigan 37.76 · 371.39 Northwestern UniversityJAMA 2015, 313, 1770.
  2. Павлов В. Н., Галимова Э. Ф., Терегулов Б. Ф., Кайбышев В. Т., Галимов. Молекулярные и метаболические аспекты мужского бесплодия. Вестник урологии 2016, 2, 40-59.
  3. Wang J., Knaut H. Chemokine signaling in development and disease. Development 2014, 141, 4199-4205.
  4. Fijak M., Bhushan S., Meinhardt A. Immunoprivileged sites: the testis. Methods Mol. Biol 2011, 677, 459-470.
  5. Sharkey D., Macpherson A., Tremellen K. TGF-β Mediates Proinflammatory Seminal Fluid Signaling in Human Cervical Epithelial Cells. J. Immunol. 2012, 189 (2), 1024-1035.

版权所有 © Galimova E.F., Gaysina A.R., Travnikov O.Y., Bulygin K.V., Akhmadullina G.H., Galimov S.N., 2017

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