IMBALANCE OF CHEMOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF MALE INFERTILITY

Cover Page

Cite item

Full Text

Abstract

The aim of study was to evaluate the role of chemokines and growth factors in the development of idiopathic infertility. In serum and seminal plasma of the infertile men the deficit and the imbalance of stromal cell factors SDF-1α and transforming growth factor TGFβ, spermatogenesis and modulators of the immune response in the reproductive system are identified. Possible mechanisms for the negative impact of the identified features of the cytokine profile on the fertilizing capacity of sperm were discussed.

About the authors

E. F. Galimova

Bashkir State Medial University

Author for correspondence.
Russian Federation

A. R. Gaysina

Bashkir State Medial University

Russian Federation

O. Yu. Travnikov

Bashkir State Medial University

Russian Federation

K. V. Bulygin

Bashkir State Medial University

Russian Federation

G. H. Akhmadullina

Bashkir State Medial University

Russian Federation

S. N. Galimov

Bashkir State Medial University

Russian Federation

References

  1. Kashanian J., Brannigan R. Male Infertility. Robert E Brannigan 37.76 · 371.39 Northwestern UniversityJAMA 2015, 313, 1770.
  2. Павлов В. Н., Галимова Э. Ф., Терегулов Б. Ф., Кайбышев В. Т., Галимов. Молекулярные и метаболические аспекты мужского бесплодия. Вестник урологии 2016, 2, 40-59.
  3. Wang J., Knaut H. Chemokine signaling in development and disease. Development 2014, 141, 4199-4205.
  4. Fijak M., Bhushan S., Meinhardt A. Immunoprivileged sites: the testis. Methods Mol. Biol 2011, 677, 459-470.
  5. Sharkey D., Macpherson A., Tremellen K. TGF-β Mediates Proinflammatory Seminal Fluid Signaling in Human Cervical Epithelial Cells. J. Immunol. 2012, 189 (2), 1024-1035.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Galimova E.F., Gaysina A.R., Travnikov O.Y., Bulygin K.V., Akhmadullina G.H., Galimov S.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).