SEMAPHORIN 3A INHIBITS THYMOCYTE FUNCTIONS
- 作者: Rutto C.1, Starikova E.1, Lioudyno V.1, Kisseleva E.1,2
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隶属关系:
- Institute for Experimental Medicine
- North-Western Medical Academy named after 1.1. Mechnikov
- 期: 卷 20, 编号 3 (2017)
- 页面: 487-489
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/119798
- ID: 119798
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详细
Semaphorin 3A (Sema 3A) is known to be an axon guidance molecule and is implicated in the development of nervous system. The aim of the study was to evaluate the influence of Sema 3A on functions of murine thymocytes, such as: proliferation, migration and adhesion to thymic epithelial cells. Sema 3A suppressed thymocyte proliferation at 100 and 200 ng/ml, possessed a chemorepellent activity towards thymocytes in the transwell system, and inhibited thymocyte adhesion to murine thymic epithelial cell lines cTEC 1-2 and mTEC 3-10. Thus, Sema 3A is a negative regulator of important thymocyte functions and may essentially affect the process of thymocyte maturation.
作者简介
C. Rutto
Institute for Experimental Medicine
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
E. Starikova
Institute for Experimental Medicine
Email: noemail@neicon.ru
俄罗斯联邦
V. Lioudyno
Institute for Experimental Medicine
Email: noemail@neicon.ru
俄罗斯联邦
E. Kisseleva
Institute for Experimental Medicine; North-Western Medical Academy named after 1.1. Mechnikov
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Lepelletier Y., Smaniotto S., Hadj-Slimane R., Villa-Verde D. M. S., Nogueira A. C. et al. Control of human thymocyte migration by Neuropilin-1/ Semaphorin-3A-mediated interaction. Proc. Nat. Acad. Sci. USA. 2007, 104, 5545-5550.
- Kasai M., Hirokawa K., Kejino K., Ogasawara K., Tatsumi M. et al. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur. J. Immunol. 1996, 26, 2101-2107.
- Castellani V., Rougon G. Control of Semaphorin signaling. Curr. Opin. Neurobiol. 2002, 12, 532-541.
- Mendes-da-Cruz D.A., Lepelletier Y., Brignier A. C. et al. Neuropilins, semaphorins, and their role in thymocyte development Ann.N.Y.Acad.Sci. 2009, 1153, 20-28.
- Kim C. H., Pelus L. M., White J. R., Broxmeyer H. E. Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood 1998, 91,4434-4443.
