PROGNOSTIC SIGNIFICANCE OF CYTOKINES` TISSUE LEVELS IN SOME MALIGNANT TUMORS

Levels of cytokines TNF-α, IL-1β, IL-2, IL-6, IL-8, IL-10, IFN-α, IFN-γ were evaluated in samples of tumor and peritumoral tissue of 36 patients with esophageal cancer and 56 patients with skin melanoma in comparison with their clinical course. By means of ROC-analysis we showed that cytokines` levels in tissues are of some use for prognosis of the risk of the tumors` early progression. High levels of IL-1β and IL-6 in tumor, IL-1β and IL-2 in peritumoral tissue characterize the melanoma`s microenvironment as the most dangerous in course of negative prognosis. As for the esophageal cancer it is related to high amounts of IL-1β, IL-8 and IL-10 in tumor, IL-8 and TNF-α in peritumoral tissue, TNF-α and IL-10 in the resection line.