PECULIARITIES OF IMMUNOLOGICAL RESPONCE DURING LIVER CIRRHOSIS DEPENDING ON SEVERITY LEVEL

It has been established that the level of IL-6 in patients with subcompensated CP (class B) was significantly higher than in the compensated stage (p <0.001), and also had significant differences in patients with subcompensated and decompensated CP (p <0.001). The concentrations of VEGF and G-CSF significantly increased at the stage of severe cirrhosis (p <0.001 and p = 0.04, respectively). Proinflammatory cytokine TNF-α and anti-inflammatory IL-4 significantly increased during transition to the subcompensated stage of the disease (р=0.01 and р=0.04, respectively). There are no reliable differences between allelic variations of polymorphic gene loci TNF (G4682A), IL-6 (C174G) and VEGFA (G-634C), associated with liver cirrhosis severity levels, detected by us.

IL-6, VEGF, ген VEGFA (G-634C), цирроз печени, IL-6, VEGF, gen VEGFA (G-634C), liver cirrhosis