INTERLEUKIN-8 POTENTIATED THE PRO-INFLAMMATORY ACTIVITY OF HUMAN MONOCYTES/MACROPHAGES AND T-LYMPHOCYTES


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We investigated the direct effect of interleukin-8 (IL-8) on the functional activity of human monocytes/macrophages and T-lymphocytes. It was shown that IL-8enhanced the production of IL-6 and IL-1β by LPS-activated monocytes/macrophages. In addition, IL-8 enhanced the production of IL-2 and suppressed the production of IL-10 and IL-4 by activated T-lymphocytes. The results demonstrate the ability of IL-8 to stimulate both the pro-inflammatory (M1) activity of monocytes/macrophages, and to participate in the direct regulation of adaptive T-cell responses.

作者简介

M. Meniailo

Immanuel Kant Baltic Federal University

编辑信件的主要联系方式.
Email: max89me@yandex.ru

PhD, Researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

俄罗斯联邦

V. Malashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology, 

Kaliningrad

俄罗斯联邦

O. Melashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology,

Kaliningrad

俄罗斯联邦

E. Shunkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

junior researcher of Center of Medical Biotechnology,

Kaliningrad

俄罗斯联邦

A. Goncharov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Deputy Director of the Medical Institute for Scientific Work,

Kaliningrad

俄罗斯联邦

参考

  1. Martinez F. O., Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime reports.2014, 6: 13.
  2. Hirahara K., Nakayama T. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. International immunology. 2016, 28(4), 163–171.
  3. Meniailo M. E., Malashchenko V. V., Shmarov V. A., Gazatova N. D., Melashchenko O. B., Goncharov A. G., Seledtsova G. V., Seledtsov V. I. Direct effects of interleukin-8 on growth and functional activity of T lymphocytes. International immunopharmacology. 2017, 50, 178–185.
  4. Arango Duque G., Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Frontiers in immunology.2014, 5, 491.
  5. Hwang E. S., Hong J. H., Glimcher L. H. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. Journal of experimental medicine. 2005, 202(9), 1289–1300.

版权所有 © Meniailo M.E., Malashchenko V.V., Melashchenko O.B., Shunkin E.O., Goncharov A.G., 2019

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此作品已接受知识共享署名 4.0国际许可协议的许可
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