INTERLEUKIN-8 POTENTIATED THE PRO-INFLAMMATORY ACTIVITY OF HUMAN MONOCYTES/MACROPHAGES AND T-LYMPHOCYTES


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Abstract

We investigated the direct effect of interleukin-8 (IL-8) on the functional activity of human monocytes/macrophages and T-lymphocytes. It was shown that IL-8enhanced the production of IL-6 and IL-1β by LPS-activated monocytes/macrophages. In addition, IL-8 enhanced the production of IL-2 and suppressed the production of IL-10 and IL-4 by activated T-lymphocytes. The results demonstrate the ability of IL-8 to stimulate both the pro-inflammatory (M1) activity of monocytes/macrophages, and to participate in the direct regulation of adaptive T-cell responses.

About the authors

M. E. Meniailo

Immanuel Kant Baltic Federal University

Author for correspondence.
Email: max89me@yandex.ru

PhD, Researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

V. V. Malashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology, 

Kaliningrad

Russian Federation

O. B. Melashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology,

Kaliningrad

Russian Federation

E. O. Shunkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

junior researcher of Center of Medical Biotechnology,

Kaliningrad

Russian Federation

A. G. Goncharov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Deputy Director of the Medical Institute for Scientific Work,

Kaliningrad

Russian Federation

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  3. Meniailo M. E., Malashchenko V. V., Shmarov V. A., Gazatova N. D., Melashchenko O. B., Goncharov A. G., Seledtsova G. V., Seledtsov V. I. Direct effects of interleukin-8 on growth and functional activity of T lymphocytes. International immunopharmacology. 2017, 50, 178–185.
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Copyright (c) 2019 Meniailo M.E., Malashchenko V.V., Melashchenko O.B., Shunkin E.O., Goncharov A.G.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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