THE LEVEL OF THE INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES IN COPROFILTRATES OF THE PATIENTS WITH REACTIVE ARTHRITIS DEPENDING ON THE DEGREE OF INTESTINAL DYSBIOSIS

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A comparative clinical and immunological examination of children with reactive arthritis (ReA) and healthy revealed an increase in the level of pro-infl ammatory (INF-γ, TNF-α, IL-6) and anti-infl ammatory (IL-10) cytokines in coprofilters depending on the increase in the severity of dysbiotic disorders of the intestinal microbiota, which indicates the possibility of using these criterions as diagnostic and prognostic markers of Re A.

作者简介

E. Danilova

Orenburg State Medical University, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: danilowa@list.ru

Ph.D., Docent of the Department of Pharmaceutical Chemistry,

Orenburg

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O. Chelpachenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

M.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis, 

Orenburg

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I. Chainikova

Orenburg State Medical University, Ministry of Health of the Russian Federation;
Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

M.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis,

Orenburg

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E. Ivanova

Orenburg State Medical University, Ministry of Health of the Russian Federation;
Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Docent of the Department of Pharmaceutical Chemistry;

Leading Researcher Institute of Cellular and Intracellular Symbiosis, 

Orenburg

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I. Nikiforov

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Ph.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis,

Orenburg

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参考

  1. Ohland C. L., Jobin C. Microbial activities and intestinal homeostasis: A delicate balance between health and disease.Cell Mol Gastroenterol Hepatol., 2015; 1(1): 28–40.
  2. Yeoh N., Burton J. P., Suppiah P., Reid G., Stebbings S. The role of the microbiome in rheumatic diseases. Curr. Rheumatol. Rep., 2013;15:314.

版权所有 © Danilova E.I., Chelpachenko O.E., Chainikova I.N., Ivanova E.V., Nikiforov I.A., 2019

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