THE LEVEL OF THE INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES IN COPROFILTRATES OF THE PATIENTS WITH REACTIVE ARTHRITIS DEPENDING ON THE DEGREE OF INTESTINAL DYSBIOSIS
- Authors: Danilova E.I.1, Chelpachenko O.E.2, Chainikova I.N.1,2, Ivanova E.V.1,2, Nikiforov I.A.2
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Affiliations:
- Orenburg State Medical University, Ministry of Health of the Russian Federation
- Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 224-226
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119618
- DOI: https://doi.org/10.31857/S102872210006582-5
- ID: 119618
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Abstract
A comparative clinical and immunological examination of children with reactive arthritis (ReA) and healthy revealed an increase in the level of pro-infl ammatory (INF-γ, TNF-α, IL-6) and anti-infl ammatory (IL-10) cytokines in coprofilters depending on the increase in the severity of dysbiotic disorders of the intestinal microbiota, which indicates the possibility of using these criterions as diagnostic and prognostic markers of Re A.
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About the authors
E. I. Danilova
Orenburg State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: danilowa@list.ru
Ph.D., Docent of the Department of Pharmaceutical Chemistry,
Orenburg
Russian FederationO. E. Chelpachenko
Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
M.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis,
Orenburg
Russian FederationI. N. Chainikova
Orenburg State Medical University, Ministry of Health of the Russian Federation;Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
M.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis,
Orenburg
Russian FederationE. V. Ivanova
Orenburg State Medical University, Ministry of Health of the Russian Federation;Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
Docent of the Department of Pharmaceutical Chemistry;
Leading Researcher Institute of Cellular and Intracellular Symbiosis,
Orenburg
Russian FederationI. A. Nikiforov
Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
Ph.D., Leading Researcher Institute of Cellular and Intracellular Symbiosis,
Orenburg
Russian FederationReferences
- Ohland C. L., Jobin C. Microbial activities and intestinal homeostasis: A delicate balance between health and disease.Cell Mol Gastroenterol Hepatol., 2015; 1(1): 28–40.
- Yeoh N., Burton J. P., Suppiah P., Reid G., Stebbings S. The role of the microbiome in rheumatic diseases. Curr. Rheumatol. Rep., 2013;15:314.
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