STUDYING OF THE ASSOCIATION BETWEEN HLA-G GENE POLYMORPHISM AND RISK RECURRENT MISCARRIAGE IN WOMEN WITH PERSISTENT BACTERIAL-VIRAL INFECTION

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The associations between polymorphisms HLA-G (rs41551813, rs12722477, rs41557518 and rs16375) and recurrent miscarriage and risk of recurrent miscarriage (RM) in women with persistent bacterial-viral infection were investigated. It is found that the HLA-G rs12722477 110Ile allele is associated with the risk of RM only in women with persistent bacterial-viral infection (OR=2,49 (1,91–5,21); Pс=0,04).

作者简介

L. Gordeeva

Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)

编辑信件的主要联系方式.
Email: ihe@kemtel.ru

PhD, leading researcher of Laboratory Immunogenetics,

Kemerovo

俄罗斯联邦

E. Voronina

Institute of Chemical Biology and Fundamental Medicine SB RAS

Email: fake@neicon.ru

PhD, researcher of Laboratory Pharmacogenomics,

Novosibirsk

俄罗斯联邦

E. Polenok

Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)

Email: fake@neicon.ru

PhD, leading researcher of Laboratory Immunochemistry,

Kemerovo

俄罗斯联邦

S. Mun

Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)

Email: fake@neicon.ru

PhD, senior researcher of Laboratory Immunogenetics,

Kemerovo

俄罗斯联邦

R. Olennikova

Kemerovo Regional Clinical Hospital, Genetic Consultation

Email: fake@neicon.ru

geneticist,

Kemerovo

俄罗斯联邦

M. Filipenko

Institute of Chemical Biology and Fundamental Medicine SB RAS

Email: fake@neicon.ru

PhD, Head of Laboratory Pharmacogenomics,

Novosibirsk

俄罗斯联邦

A. Glushkov

Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)

Email: fake@neicon.ru

MD, deputy director,

Kemerovo

俄罗斯联邦

参考

  1. L. Lynge Nilsson, S. Djurisic, T. V. Hviid. Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction. Front Immunol. 2014, 13, 198, https://doi.org/10.3389/fimmu.2014.00198

版权所有 © Gordeeva L.A., Voronina E.N., Polenok E.G., Mun S.A., Olennikova R.V., Filipenko M.L., Glushkov A.N., 2019

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