STUDYING OF THE ASSOCIATION BETWEEN HLA-G GENE POLYMORPHISM AND RISK RECURRENT MISCARRIAGE IN WOMEN WITH PERSISTENT BACTERIAL-VIRAL INFECTION
- Authors: Gordeeva L.A.1, Voronina E.N.2, Polenok E.G.1, Mun S.A.1, Olennikova R.V.3, Filipenko M.L.2, Glushkov A.N.1
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Affiliations:
- Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
- Institute of Chemical Biology and Fundamental Medicine SB RAS
- Kemerovo Regional Clinical Hospital, Genetic Consultation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 218-220
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119604
- DOI: https://doi.org/10.31857/S102872210006466-7
- ID: 119604
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Abstract
The associations between polymorphisms HLA-G (rs41551813, rs12722477, rs41557518 and rs16375) and recurrent miscarriage and risk of recurrent miscarriage (RM) in women with persistent bacterial-viral infection were investigated. It is found that the HLA-G rs12722477 110Ile allele is associated with the risk of RM only in women with persistent bacterial-viral infection (OR=2,49 (1,91–5,21); Pс=0,04).
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About the authors
L. A. Gordeeva
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
Author for correspondence.
Email: ihe@kemtel.ru
PhD, leading researcher of Laboratory Immunogenetics,
Kemerovo
Russian FederationE. N. Voronina
Institute of Chemical Biology and Fundamental Medicine SB RAS
PhD, researcher of Laboratory Pharmacogenomics,
Novosibirsk
Russian FederationE. G. Polenok
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
PhD, leading researcher of Laboratory Immunochemistry,
Kemerovo
Russian FederationS. A. Mun
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
PhD, senior researcher of Laboratory Immunogenetics,
Kemerovo
Russian FederationR. V. Olennikova
Kemerovo Regional Clinical Hospital, Genetic Consultation
geneticist,
Kemerovo
Russian FederationM. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine SB RAS
PhD, Head of Laboratory Pharmacogenomics,
Novosibirsk
Russian FederationA. N. Glushkov
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
MD, deputy director,
Kemerovo
Russian FederationReferences
- L. Lynge Nilsson, S. Djurisic, T. V. Hviid. Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction. Front Immunol. 2014, 13, 198, https://doi.org/10.3389/fimmu.2014.00198
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