STUDYING OF THE ASSOCIATION BETWEEN HLA-G GENE POLYMORPHISM AND RISK RECURRENT MISCARRIAGE IN WOMEN WITH PERSISTENT BACTERIAL-VIRAL INFECTION
- Authors: Gordeeva L.A.1, Voronina E.N.2, Polenok E.G.1, Mun S.A.1, Olennikova R.V.3, Filipenko M.L.2, Glushkov A.N.1
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Affiliations:
- Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
- Institute of Chemical Biology and Fundamental Medicine SB RAS
- Kemerovo Regional Clinical Hospital, Genetic Consultation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 218-220
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119604
- DOI: https://doi.org/10.31857/S102872210006466-7
- ID: 119604
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Abstract
The associations between polymorphisms HLA-G (rs41551813, rs12722477, rs41557518 and rs16375) and recurrent miscarriage and risk of recurrent miscarriage (RM) in women with persistent bacterial-viral infection were investigated. It is found that the HLA-G rs12722477 110Ile allele is associated with the risk of RM only in women with persistent bacterial-viral infection (OR=2,49 (1,91–5,21); Pс=0,04).
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About the authors
L. A. Gordeeva
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
Author for correspondence.
Email: ihe@kemtel.ru
PhD, leading researcher of Laboratory Immunogenetics,
Kemerovo
Russian FederationE. N. Voronina
Institute of Chemical Biology and Fundamental Medicine SB RAS
Email: fake@neicon.ru
PhD, researcher of Laboratory Pharmacogenomics,
Novosibirsk
Russian FederationE. G. Polenok
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
Email: fake@neicon.ru
PhD, leading researcher of Laboratory Immunochemistry,
Kemerovo
Russian FederationS. A. Mun
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
Email: fake@neicon.ru
PhD, senior researcher of Laboratory Immunogenetics,
Kemerovo
Russian FederationR. V. Olennikova
Kemerovo Regional Clinical Hospital, Genetic Consultation
Email: fake@neicon.ru
geneticist,
Kemerovo
Russian FederationM. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine SB RAS
Email: fake@neicon.ru
PhD, Head of Laboratory Pharmacogenomics,
Novosibirsk
Russian FederationA. N. Glushkov
Federal Research Center of Coal and Coal Chemistry SB RAS (Institute of Human Ecology SB RAS)
Email: fake@neicon.ru
MD, deputy director,
Kemerovo
Russian FederationReferences
- L. Lynge Nilsson, S. Djurisic, T. V. Hviid. Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction. Front Immunol. 2014, 13, 198, https://doi.org/10.3389/fimmu.2014.00198
