INFLUENCE OF "TSITOVIRA-3" ON THE EXPRESSION OF IL-8 AND ICAM-1MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY926 INVITRO LINE

T. A. Kudryavtseva; Кудрявцева Т. А.; E. A. Starikova; Старикова Э. А.; N. A. Aktureeva; Актуреева Н. А.; S. V. Petlenko; Петленко С. В.; V. S. Smirnov; Смирнов В. С.; N. I. Stukan; Стукань Н. И.; A. V. Lyovina; Лёвина А. В.

INFLUENCE OF "TSITOVIRA-3" ON THE EXPRESSION OF IL-8 AND ICAM-1MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY926 INVITRO LINE

作者: Kudryavtseva T.¹, Starikova E.², Aktureeva N.², Petlenko S.¹, Smirnov V.¹, Stukan N.¹, Lyovina A.¹
隶属关系:
1. ZAO "MBNPK "Cytomed"
2. Institute of Experimental Medicine
期: 卷 20, 编号 2 (2017)
页面: 155-156
栏目: Articles
URL: https://journals.rcsi.science/1028-7221/article/view/119590
ID: 119590

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The aim of the current study was to investigate cell mechanisms by means of which the "Cytovir-3", the drug for prevention and treatment of the influenza and acute respiratory viral infection, exerts its pharmacological effects. As a cellular model, an endothelial EA.hy926 as well as mononuclear leukocytes (ML) of human peripheral blood were chosen. The effects of co-incubation of "Cytovir-3" and cell lines on IL-8 and ICAM-1 expression were evaluated. In the presence of "Cytovir-3" at concentration of 10.0 ng/ml and 1.0 ng/ml, we found a significant increase in spontaneous secretion of IL-8 by endothelial cells by 10 % and 15 % accordingly. Besides, at concentration of 10.0 ng/ml the investigating drug significantly enhanced the expression level of ICAM-1 induced by TNFa. Revealed stimulating action of "Cytovir-3" on endothelial cells and ML can suggest its influence on vascular component of inflammatory reaction.

关键词

Цитовир-3, эндотелиальные клетки EA.hy926, мононуклеарные лейкоциты периферической крови человека, ICAM-1, секреция цитокинов, Tsitovir-3, endotelialny cages of EA.hy 926, mononuclear leukocytes of peripheral blood of the person, ICAM-1, secretion of cytokins

参考

Смирнов В. С. Современные средства профилактики и лечения гриппа и ОРВИ. СПб: ФАР-МИндекс. - 2010. - ISBN 978-5-91753-015-4.
Smirnov V. S. Modern drugs of prevention and treatment of influenza and acute respiratory viral infections. SPb: PHARMIndex.- 2010.- ISBN 978-5-91753-015-4.
Gasparini R., Amicizia D., Lai P. L., Bragazzi N. L., Panatto D. Journal of Preventive Medicine and Hygiene- 2014.- V.55.- № 4.- Р.109-29.
Soema P. C., Kompier R., Amorij J. P., Kersten G. F. European Journal Of Pharmaceutics And Biophar-maceutics. 2015. V.94. P. 251-63.

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INFLUENCE OF "TSITOVIRA-3" ON THE EXPRESSION OF IL-8 AND ICAM-1MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY926 INVITRO LINE

全文:

详细

关键词

作者简介

T. Kudryavtseva

E. Starikova

N. Aktureeva

S. Petlenko

V. Smirnov

N. Stukan

A. Lyovina

参考