INFLUENCE OF "TSITOVIRA-3" ON THE EXPRESSION OF IL-8 AND ICAM-1MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY926 INVITRO LINE

Cover Page

Cite item

Full Text

Abstract

The aim of the current study was to investigate cell mechanisms by means of which the "Cytovir-3", the drug for prevention and treatment of the influenza and acute respiratory viral infection, exerts its pharmacological effects. As a cellular model, an endothelial EA.hy926 as well as mononuclear leukocytes (ML) of human peripheral blood were chosen. The effects of co-incubation of "Cytovir-3" and cell lines on IL-8 and ICAM-1 expression were evaluated. In the presence of "Cytovir-3" at concentration of 10.0 ng/ml and 1.0 ng/ml, we found a significant increase in spontaneous secretion of IL-8 by endothelial cells by 10 % and 15 % accordingly. Besides, at concentration of 10.0 ng/ml the investigating drug significantly enhanced the expression level of ICAM-1 induced by TNFa. Revealed stimulating action of "Cytovir-3" on endothelial cells and ML can suggest its influence on vascular component of inflammatory reaction.

About the authors

T. A. Kudryavtseva

ZAO "MBNPK "Cytomed"

Author for correspondence.
Russian Federation

E. A. Starikova

Institute of Experimental Medicine

Russian Federation

N. A. Aktureeva

Institute of Experimental Medicine

Russian Federation

S. V. Petlenko

ZAO "MBNPK "Cytomed"

Russian Federation

V. S. Smirnov

ZAO "MBNPK "Cytomed"

Russian Federation

N. I. Stukan

ZAO "MBNPK "Cytomed"

Russian Federation

A. V. Lyovina

ZAO "MBNPK "Cytomed"

Russian Federation

References

  1. Смирнов В. С. Современные средства профилактики и лечения гриппа и ОРВИ. СПб: ФАР-МИндекс. - 2010. - ISBN 978-5-91753-015-4.
  2. Smirnov V. S. Modern drugs of prevention and treatment of influenza and acute respiratory viral infections. SPb: PHARMIndex.- 2010.- ISBN 978-5-91753-015-4.
  3. Gasparini R., Amicizia D., Lai P. L., Bragazzi N. L., Panatto D. Journal of Preventive Medicine and Hygiene- 2014.- V.55.- № 4.- Р.109-29.
  4. Soema P. C., Kompier R., Amorij J. P., Kersten G. F. European Journal Of Pharmaceutics And Biophar-maceutics. 2015. V.94. P. 251-63.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Kudryavtseva T.A., Starikova E.A., Aktureeva N.A., Petlenko S.V., Smirnov V.S., Stukan N.I., Lyovina A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).