SUBPOPULATIONS OF MYELOID DERIVED SUPRESSORS CELLS IN CHILDREN WITH PSORIASIS
- 作者: Gerasimova D.1, Radygina T.1, Zakirov R.1, Ambarchyan A.1, Materikin A.1, Epishev N.1, Murashkin A.1, Petrichuk S.1
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隶属关系:
- National Medical Research Center for Children’s Health
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 200-201
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119554
- DOI: https://doi.org/10.31857/S102872210006457-7
- ID: 119554
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详细
The absolute and relative number of myeloid derived suppressor cells, regulatory T-lymphocytes and Th17-lymphocytes were assessed in 115 patients with psoriasis and 53 healthy children aged 1.5 to 18 years. An increase in the number of MDSCs due to G-MDSCs was found, depending on the duration of the disease. As the severity of the disease increases, the relative number of M-MDSCs increases. The number of MDSCs directly correlates with the number of Th17 lymphocytes and Treg.
作者简介
D. Gerasimova
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
resident, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦T. Radygina
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
Ph D., Senior Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦R. Zakirov
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
Doctor of clinical laboratory,
Moscow
俄罗斯联邦A. Ambarchyan
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
Research Associate, Laboratory Skin Phatology in children,
Moscow
俄罗斯联邦A. Materikin
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
Dermatologist, Department of Dermatology,
Moscow
俄罗斯联邦N. Epishev
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
Dermatovenerologist, Department of Dermatology,
Moscow
俄罗斯联邦A. Murashkin
National Medical Research Center for Children’s Health
Email: fake@neicon.ru
PhD, MD, Head of the Laboratory Skin Phatology in children,
Moscow
俄罗斯联邦S. Petrichuk
National Medical Research Center for Children’s Health
编辑信件的主要联系方式.
Email: cito@list.ru
PhD, MD (Biology), Professor, Principal Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦参考
- Ilkovitch D., Ferris L. K. Myeloid-derived suppressor cells are elevated in patients with psoriasis and produce various molecules //Mol Med Rep,2016.14(4). рр3935–40.
- Козлов В. А. Клетки-супресоры – основа иммунопатогенеза аутоиммунных заболеваний // Медицинская иммунология, 2016. Т. 18, № 1. С. 7–14.
- Budhwar S., Verma P., Verma R., Rai S., Singh K. The Yin and Yang of Myeloid Derived Suppressor Cells // Front Immunol, 2018.Vol.9, p.2776.
- Lyadova I., Sosunova E., Nikolaev A., Nenasheva T. Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation// Journal of Immunology Research, Vol. 2016, Article ID7121580, 17 p.
- Zhu J., Chen S., Wu L., Wang R., Zheng S., Zhao D., Wang X, Li J. The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Infl ammation in Rheumatic Patients with Arthritis // Bio Med Research International, Vol. 2018, Article ID5474828, 12 p.
