SUBPOPULATIONS OF MYELOID DERIVED SUPRESSORS CELLS IN CHILDREN WITH PSORIASIS
- Authors: Gerasimova D.G.1, Radygina T.V.1, Zakirov R.S.1, Ambarchyan A.I.1, Materikin A.I.1, Epishev N.N.1, Murashkin A.I.1, Petrichuk S.V.1
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Affiliations:
- National Medical Research Center for Children’s Health
- Issue: Vol 22, No 2-1 (2019)
- Pages: 200-201
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119554
- DOI: https://doi.org/10.31857/S102872210006457-7
- ID: 119554
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Abstract
The absolute and relative number of myeloid derived suppressor cells, regulatory T-lymphocytes and Th17-lymphocytes were assessed in 115 patients with psoriasis and 53 healthy children aged 1.5 to 18 years. An increase in the number of MDSCs due to G-MDSCs was found, depending on the duration of the disease. As the severity of the disease increases, the relative number of M-MDSCs increases. The number of MDSCs directly correlates with the number of Th17 lymphocytes and Treg.
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About the authors
D. G. Gerasimova
National Medical Research Center for Children’s Health
resident, Laboratory of Experimental Immunology and Virology,
Moscow
Russian FederationT. V. Radygina
National Medical Research Center for Children’s Health
Ph D., Senior Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
Russian FederationR. Sh. Zakirov
National Medical Research Center for Children’s Health
Doctor of clinical laboratory,
Moscow
Russian FederationA. I. Ambarchyan
National Medical Research Center for Children’s Health
Research Associate, Laboratory Skin Phatology in children,
Moscow
Russian FederationA. I. Materikin
National Medical Research Center for Children’s Health
Dermatologist, Department of Dermatology,
Moscow
Russian FederationN. N. Epishev
National Medical Research Center for Children’s Health
Dermatovenerologist, Department of Dermatology,
Moscow
Russian FederationA. I. Murashkin
National Medical Research Center for Children’s Health
PhD, MD, Head of the Laboratory Skin Phatology in children,
Moscow
Russian FederationS. V. Petrichuk
National Medical Research Center for Children’s Health
Author for correspondence.
Email: cito@list.ru
PhD, MD (Biology), Professor, Principal Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
Russian FederationReferences
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