REACTIONS HAVE DIFFERENCES OF PHAGOCYTES OF PERIPHERAL BLOOD OF PATIENTS WITH DIFFERENT VOLUMES AFFECTED LUNG INFILTRATIVE TUBERCULOSIS

The purpose of research is the study of differences in the reactions of phagocytes of peripheral blood of patients with different lesion volume infiltrative pulmonary tuberculosis. The work was based on a study of the clinical and laboratory data of 44 patients with infiltrative pulmonary tuberculosis (29 patients were affected lung segment 1-3, 15 patients had tuberculosis 4 and lighter segments). The control group consisted of 25 healthy people. Used method - flow cytometry, Coulter*Epics*XL instrument (Beckman Coulter, USA). Evaluated absorbency peripheral blood phagocytes (monocytes and neutrophils), ability to oxidative exposure, the antigen-presenting and chemotactic functions. Statistical data analysis was performed using the «Microsoft Office Excel 2007" program and «Statistica For Windows v.6.1». It was found that the infiltrative tuberculosis 1-3 segments of the lung accompanied by an increase in the populations of monocytes and granulocytes which express the molecule CD11b adhesion. TB 4 or more segments of the lung is associated with an increase in the number of monocytes and granulocytes expressing CD11c, decrease monocyte production of superoxide anion. Immunological evaluation of lung volume criterion is the percentage of monocytes, producing superoxide anion.

моноцит, нейтрофил, СD11с, HLA-DR, туберкулез, monocytes, neutrophils, СD11c, HLA-DR, tuberculosis