Assessment of the role of WIF-1 in the genesis of ischemic heart disease

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Coronary heart disease poses one of the most serious threats to human health resulting in enormous physical and economic losses worldwide. WNT signaling pathways play an important role in cardiogenesis both in embryogenesis and cardiac repair after previous ischemic attacks that motivated to conduct this study.
The aim of the study was to examine features of WIF-1 production in patients with coronary heart disease. There were enrolled 60 patients with a clinically verified and diagnosed coronary artery disease. WIF-1 serum concentration was measured by using enzyme-linked immunosorbent assay presenting data as absolute numbers (n, %) or medians, 1 and 3 quartiles – Me (Q0.25-Q0.75). Analyzing study data showed that WIF-1 serum concentration in patients with myocardial infarction was 2890 (1700-3337.5) pg/ml being by 7.97-fold higher than that one in healthy individuals (p <0.001), in agreement with previous studies. Moreover, in patients with angina pectoris WIF-1 serum level comprised 2170 (1493-2650) pg/ml, exceeding that one in healthy individuals by 6.14-fold (p < 0.001). Thus, the data obtained regarding changes in serum WNT-inhibiting factor-1 concentration in patients with coronary heart disease expand our understanding about an impact from affected WNT-signaling pathway components in pathogenesis of inflammatory process during hypoxic injuries.

作者简介

M. Plotnikova

I. Turgenev Oryol State University

编辑信件的主要联系方式.
Email: ekb-lem@mail.ru

Plotnikova Maria O. - Senior Lecturer, Department of Immunology and Specialized Clinical Disciplines

302026, Oryol, Komsomolskaya str., 95

Phone: 7 (905) 802-15-39

俄罗斯联邦

I. Snimshchikova

I. Turgenev Oryol State University

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Head, Department of Immunology and Specialized Clinical Disciplines, Director of Medical Institute

Oryol

俄罗斯联邦

I. Afoninа

I. Turgenev Oryol State University

Email: fake@neicon.ru

PhD (Medicine), Associate Professor, Department of Immunology and Specialized Clinical Disciplines

Oryol

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A. Kulakova

Bryansk Regional Hospital No. 1

Email: fake@neicon.ru

Gastroenterologist

Bryansk

俄罗斯联邦

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版权所有 © Plotnikova M.O., Snimshchikova I.A., Afoninа I.A., Kulakova A.S., 2020

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