ASSESSMENT OF THE FUNCTIONAL ACTIVITY OF ENDOTHELIUM IN WOMEN WITH HEAVY PREECLAMPSIA DEPENDING MANIFESTATIONS OF THE DISEASE
- 作者: Chistyakova G.N.1, Remizovа I.I.1, Aitov A.E.1
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隶属关系:
- Ural Scientific Research Institute of Maternity and Child Care
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 641-643
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120328
- DOI: https://doi.org/10.31857/S102872210006999-3
- ID: 120328
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详细
The functional activity of the endothelium and the level of pro- and anti-inflammatory mediators in women with severe pre-eclampsia (PE) were evaluated depending on the onset of the disease. It was established that the implementation of severe pre-eclampsia regardless of the timing of the manifestation (before or after 34 weeks of gestation) is accompanied by an increase in the level of endothelin-1, TNFα and C-reactive protein. In women with early PE, against the background of the revealed changes, an increase in the level of stable NO2 and IL-10 metabolites is noted, and from late PE, there is a homocysteine content, which makes it possible to use these indicators to assess the severity of preeclampsia with different periods
作者简介
G. Chistyakova
Ural Scientific Research Institute of Maternity and Child Care
Email: omm@niiomm.ru
MD, Professor, Head of the Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
俄罗斯联邦I. Remizovа
Ural Scientific Research Institute of Maternity and Child Care
编辑信件的主要联系方式.
Email: RemizovaII@yandex.ru
Ph.D., Senior Researcher Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
俄罗斯联邦A. Aitov
Ural Scientific Research Institute of Maternity and Child Care
correspondence postgraduate student,
Yekaterinburg
俄罗斯联邦参考
- Ходжаева З. С., Холин А. М., Вихляева Е. М. Ранняя и поздняя преэклампсия: парадигмы патобиологии и клиническая практика. Акушерство и гинекология, 2013, 10, 4–11.
- Schiessl B. Infl ammatory response in preeclampsia. Mol Aspects Med 2007, 28 (2), 210–219.
- Bonney E. A. Preeclampsia: a view through the danger model. J Reprod Immunol 2007; 76(1–2), 68–74.
- Шишкин А. Н., Лындина М. Л. Эндотелиальная дисфункция и артериальная гипертензия. Артериальная гипертензия. 2008, 14(4), 315–18.
- Чистякова Г. Н., Ремизова И. И., Бычкова С. В. Функциональная активность эндотелия у рожениц с хронической артериальной гипертензией и пациенток с преэклампсией. Медицинская иммунология. 2017, 19(S), 198–199.
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