ASSESSMENT OF THE FUNCTIONAL ACTIVITY OF ENDOTHELIUM IN WOMEN WITH HEAVY PREECLAMPSIA DEPENDING MANIFESTATIONS OF THE DISEASE

The functional activity of the endothelium and the level of pro- and anti-inflammatory mediators in women with severe pre-eclampsia (PE) were evaluated depending on the onset of the disease. It was established that the implementation of severe pre-eclampsia regardless of the timing of the manifestation (before or after 34 weeks of gestation) is accompanied by an increase in the level of endothelin-1, TNFα and C-reactive protein. In women with early PE, against the background of the revealed changes, an increase in the level of stable NO2 and IL-10 metabolites is noted, and from late PE, there is a homocysteine content, which makes it possible to use these indicators to assess the severity of preeclampsia with different periods