The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs
- Authors: Kovaleva S.V.1, Nesterova I.V.1,2, Pikturno S.N.1, Chudilova G.A.1, Lomtatidze L.V.1, Teterin Y.V.1, Pirogova A.I.1, Prosolypova N.S.1, Chulkova А.M.1
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Affiliations:
- Kuban State Medical University
- P. Lumumba Peoples’ Friendship University
- Issue: Vol 26, No 3 (2023)
- Pages: 287-294
- Section: SHORT COMMUNICATIONS
- URL: https://journals.rcsi.science/1028-7221/article/view/253404
- DOI: https://doi.org/10.46235/1028-7221-10011-EOI
- ID: 253404
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Abstract
Chronic inflammatory diseases of the pelvic organs (pelvic inflammatory disease, PID) in women is among the main understudied problems in gynecology worldwide with adverse medical and socio-economic consequences, thus justifying the need for further study of immunopathogenesis and development of new approaches to treatment. Our objective was to develop new immunotherapeutic approaches to correction of combined disorders of the immune system functioning in immunocompromised women with PID and to evaluate their clinical and immunological efficacy.
55 women aged 20-40 years were examined, i.e., 35 patients with exacerbation of sluggish or recurrent PID, resistant to conventional therapy. Testiung was performed before complex treatment (study group 1 – GI- 1) and after the course (study group 2 – GI-2). Contents of T and B lymphocytes, natural killer cells (NK) (CYTOMICS FC500, USA), phagocytic and microbicidal functions of neutrophilic granulocytes (NG) were assessed in SG-1 and SG-2 before and 2-3 days after complex treatment with addition of an immunotherapeutic drug based on hexapeptide (HP) at a daily dose of 45 mg/ml intramuscularly for 10 days.
In patients from SG-1, a decrease in T cells (CD3+CD19- ) and B cells (CD3-CD19+), a 2-fold increase in the content of NK CD3-CD16+CD56+ was found, along with altered functioning of NG (deficiency of actively phagocytizing NG, a decrease in their digestive function and NADPH-oxidase activity). In SG-2 patients, the treatment was followed by restoration of the T (CD3+CD19-) and B cells (CD3-CD19+), NK cells (CD3-CD16+CD56+), like as an increase in effector functions, i.e., microbial capture by NG and their killing ability due to activation of NADPH oxidases and normalization of microbicidal reserve capacity in the NG cell population. Positive clinical effect included reduction of clinical symptoms in acute period, absence of PID exacerbations over follow-up for 6 months (85.6% of cases). Occasional exacerbations of PID were associated with medical manipulations (5.7%) and unprotected sexual contacts (5.7%).
The immunopathogenetically proven approach to correction of combined functional impairment of immune system in the women with PID shows a positive clinical and immunological effect.
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##article.viewOnOriginalSite##About the authors
Svetlana V. Kovaleva
Kuban State Medical University
Author for correspondence.
Email: 3483335@mail.ru
ORCID iD: 0000-0002-9604-5806
Doctor of Medical Sciences (MD), Associate Professor, senior researcher of the department of clinical and experimental immunology and molecular biology of the Central Scientific Research Laboratory, Associate Professor of the Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Irina V. Nesterova
Kuban State Medical University; P. Lumumba Peoples’ Friendship University
Email: inesterova1@yandex.ru
ORCID iD: 0000-0001-6071-4409
Doctor of Medical Sciences (MD), Professor, Chief Researcher, Department of Clinical and Experimental Immunology and Molecular Biology, Central Scientific Research Laboratory, Professor of the Department of Clinical Immunology, Allergology and Adaptology Faculty of Continuing Medical Education of the Medical Institute
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063; 6 st. Miklukho-Maclay, Moscow, 117198Svetlana N. Pikturno
Kuban State Medical University
Email: spikturno@yandex.ru
ORCID iD: 0000-0001-9376-3397
Postgraduate Student, Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Galina A. Chudilova
Kuban State Medical University
Email: chudilova2015@yandex.ru
ORCID iD: 0000-0001-8005-9325
Doctor of Biological Sciences, Associate Professor, head of the department of clinical and experimental immunology and molecular biology of the Central Scientific Research Laboratory, Professor of the Department of Clinical Immunology, Allergology and Laboratory Diagnostics of the Faculty of Professional Development and Professional Retraining of Specialists
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Lyudmila V. Lomtatidze
Kuban State Medical University
Email: llomtatidze@mail.ru
ORCID iD: 0000-0002-7041-7106
PhD in Biology, head of the department of clinical and experimental immunology and molecular biology of the Central Scientific Research Laboratory, Associate Professor of the Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Yuri V. Teterin
Kuban State Medical University
Email: yura.teterin.1989@mail.ru
ORCID iD: 0000-0002-3073-5070
Postgraduate Student, Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Anna I. Pirogova
Kuban State Medical University
Email: AnP1998@yandex.ru
Resident Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Natalia S. Prosolypova
Kuban State Medical University
Email: NatalyPro87@yandex.ru
Head of the Consultative and Diagnostic Department of the Clinic
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063Аlla M. Chulkova
Kuban State Medical University
Email: achulkova@bagk-med.ru
PhD (Medical Sciences), Head of the Day Hospital Clinic
Russian Federation, 4, st. Mitrofan Sedin, Krasnodar, 350063References
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