CLINICO-IMMUNOLOGICAL EVALUATION OF THE EFFECTIVENESS OF INTRAVENOUS IMMUNOGLOBULINS AS AN ADJUVANT THERAPY FOR SURGICAL SEPSIS
- Authors: Shumatov V.B.1, Lazanovich V.A.1, Krasnikov V.E.1
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Affiliations:
- State budget educational institute of higher professional education Pacific State MedicalUniversity of Ministry of health Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 666-668
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120336
- DOI: https://doi.org/10.31857/S102872210007008-3
- ID: 120336
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Abstract
We observed 46 patients with sepsis, which were divided into 2 groups. I group (25 patients) received traditional treatment, II group (21 patients) in addition to conventional therapy received enriched IVIG (IgM+IgA). Comparative assessment of the combination of intravenous immunoglobulin’s and traditional therapy indicated the clinical effectiveness of IVIG therapy, which results in reducing the severity of systemic inflammation, the severity of the disease and the mortality in patients with surgical sepsis.
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About the authors
V. B. Shumatov
State budget educational institute of higher professional education Pacific State MedicalUniversity of Ministry of health Russian Federation
Doctor of Sciences, Professor of the Department of intensive care, anesthesiology, intensive care and emergency medical services,
Vladivostok
Russian FederationV. A. Lazanovich
State budget educational institute of higher professional education Pacific State MedicalUniversity of Ministry of health Russian Federation
Author for correspondence.
Email: immuno2003@mail.ru
Ph.D., assistant professor, Department of normal and Pathological Physiology,
Russian Federation
V. E. Krasnikov
State budget educational institute of higher professional education Pacific State MedicalUniversity of Ministry of health Russian Federation
Ph.D., assistant professor, Department of normal and Pathological Physiology,
Vladivostok
Russian FederationReferences
- Busani S., Damiani E., Cavazzuti I. Intravenous immunoglobulin in septic shock: review of the mechanisms of action and meta-analysis of the clinical effectiveness. Minerva Anestesiol. 2016. Vol. 82. P. 559–572.
- Шуматов В. Б., Лазанович В. А., Павлов В. А., Ермакова Н. Д., Просекова Е. В. Внутривенные иммуноглобулины в адъювантной терапии сепсиса. Тихоокеанский медицинский журнал, 2017. № 242 С. 42–45.
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