ANALYSIS OF PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF SUPPRESSOR POPULATIONS IN BRONCHIAL ASTHMA
- Authors: Shevchenko J.A.1, Kuznetsova M.S.1, Lopatnikova Y.A.1, Demina D.V.1, Sennikova J.A.2, Vorobyova O.P.1,3
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Affiliations:
- Research Institute of Fundamental and Clinical Immunology
- Novosibirsk State Medical University
- Novosibirsk National Research State University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 650-652
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120331
- DOI: https://doi.org/10.31857/S102872210007003-8
- ID: 120331
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Abstract
In patients with atopic allergic diseases, the number or functional characteristics of T-regulatory cells may be insufficient. The determination of the phenotypic characteristics of T-regulatory cells also makes a significant contribution to such a large variety of data obtained. The main difficulties in finding correlations between suppressor populations and the development of pathogenetic processes: the absence of a well-defined set of markers for T-regulatory cells, dependence on the stage of the disease, the duration of taking glucocorticosteroids and other drugs. No less important in studying the involvement of T-regulatory cells in the development of pathological reactions is not only the analysis of the content of T-regulatory cells, but also the assessment of their functional activity, the level of expression of membrane-bound functional molecules and the production of soluble factors by them.
About the authors
J. A. Shevchenko
Research Institute of Fundamental and Clinical Immunology
Author for correspondence.
Email: shevcen@ngs.ru
Ph.D., Senior Researcher, Laboratory of Molecular Immunology,
Novosibirsk
Russian FederationM. S. Kuznetsova
Research Institute of Fundamental and Clinical Immunology
Junior Researcher, Laboratory of Molecular Immunology,
Novosibirsk
Russian FederationYu. A. Lopatnikova
Research Institute of Fundamental and Clinical Immunology
PhD, Senior Researcher, Laboratory of Molecular Immunology,
Novosibirsk
Russian FederationD. V. Demina
Research Institute of Fundamental and Clinical Immunology
PhD, Head of Allergology Department, Clinic of Immunopathology,
Novosibirsk
Russian FederationJ. A. Sennikova
Novosibirsk State Medical University
PhD, Associate Professor, Department of Clinical Immunology,
Novosibirsk
Russian FederationO. P. Vorobyova
Research Institute of Fundamental and Clinical Immunology;Novosibirsk National Research State University
PhD, Researcher, Laboratory of Molecular Immunology;
Lecturer, Department of Clinical Biochemistry, Institute of Medicine and Psychology. V. Zelman,
Novosibirsk
Russian FederationReferences
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