ANALYSIS OF PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF SUPPRESSOR POPULATIONS IN BRONCHIAL ASTHMA

J. A. Shevchenko; Шевченко Ю. А.; M. S. Kuznetsova; Кузнецова М. С.; Yu. A. Lopatnikova; Лопатникова Ю. А.; D. V. Demina; Демина Д. В.; J. A. Sennikova; Сенникова Ю. А.; O. P. Vorobyova; Воробьева О. П.

doi:10.31857/S102872210007003-8

ANALYSIS OF PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF SUPPRESSOR POPULATIONS IN BRONCHIAL ASTHMA

作者: Shevchenko J.¹, Kuznetsova M.¹, Lopatnikova Y.¹, Demina D.¹, Sennikova J.², Vorobyova O.¹^,3
隶属关系:
1. Research Institute of Fundamental and Clinical Immunology
2. Novosibirsk State Medical University
3. Novosibirsk National Research State University
期: 卷 22, 编号 2-1 (2019)
页面: 650-652
栏目: ORIGINAL ARTICLES
URL: https://journals.rcsi.science/1028-7221/article/view/120331
DOI: https://doi.org/10.31857/S102872210007003-8
ID: 120331

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In patients with atopic allergic diseases, the number or functional characteristics of T-regulatory cells may be insufficient. The determination of the phenotypic characteristics of T-regulatory cells also makes a significant contribution to such a large variety of data obtained. The main difficulties in finding correlations between suppressor populations and the development of pathogenetic processes: the absence of a well-defined set of markers for T-regulatory cells, dependence on the stage of the disease, the duration of taking glucocorticosteroids and other drugs. No less important in studying the involvement of T-regulatory cells in the development of pathological reactions is not only the analysis of the content of T-regulatory cells, but also the assessment of their functional activity, the level of expression of membrane-bound functional molecules and the production of soluble factors by them.