TRITERPENOID MILIACINE AS A PROTECTOR OF CHROMOSOMAL ABERRATIONS INDUCED BY CYCLOPHOSPHAMIDE IN MICE BONE MARROW CELLS

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Abstract

A study of the antimutagenic eff ect of miliacin, assessed by indicators of chromosomal aberrations in mice bone marrow cells under the conditions of cyclophosphamide use, was carried out. Triterpenoid protected the mutagenic action of cyclophosphamide by the signifi cant reduction of the relative content of aberrant cells and the number of aberrations, which makes it possible to evaluate it as a promising antimutagenic agent.

About the authors

Yu. A. Sarycheva

Orenburg State Medical University

Author for correspondence.

associate professor of the Department of Pathological Physiology,

Orenburg 

Russian Federation

A. A. Tokareva

Orenburg State Medical University

assistant of the Department of Pathological Physiology,

Orenburg 

Russian Federation

T. V. Panfilova

Orenburg State Medical University

associate professor of the Department of Pathological Physiology,

Orenburg 

Russian Federation

A. D. Zheleznova

Orenburg State Medical University

associate professor of the Department of Pathological Physiology,

Orenburg 

Russian Federation

B. A. Frolov

Orenburg State Medical University

Email: K_pathphys@orgma.ru

MD, professor, Head of the Department of Pathological Physiology, 

Orenburg 

Russian Federation

References

  1. Курмуков И. А. Лекарственное поражение печени при лечении онкогематологических заболеваний. Клиническая онкогематология 2010,3(1), 60–66.
  2. Фролов Б. А., Калинина О. В., Кириллова А. В., Штиль А. А. Преодоление гепатотоксичности метотрексата. Клиническая онкогематология 2013, 6(1), 1–10.
  3. Frolov B. A., Kirillova A. V. Miliacine as a membranoprotector. The protective miliacine action under detergent-induced immunosupression. Russian Journal of Allergy 2011,4(1), 402–403.

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Copyright (c) 2019 Sarycheva Y.A., Tokareva A.A., Panfilova T.V., Zheleznova A.D., Frolov B.A.

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