TRITERPENOID MILIACINE AS A PROTECTOR OF CHROMOSOMAL ABERRATIONS INDUCED BY CYCLOPHOSPHAMIDE IN MICE BONE MARROW CELLS
- Authors: Sarycheva Y.A.1, Tokareva A.A.1, Panfilova T.V.1, Zheleznova A.D.1, Frolov B.A.1
-
Affiliations:
- Orenburg State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 527-529
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120291
- DOI: https://doi.org/10.31857/S102872210006953-3
- ID: 120291
Cite item
Full Text
Abstract
A study of the antimutagenic eff ect of miliacin, assessed by indicators of chromosomal aberrations in mice bone marrow cells under the conditions of cyclophosphamide use, was carried out. Triterpenoid protected the mutagenic action of cyclophosphamide by the signifi cant reduction of the relative content of aberrant cells and the number of aberrations, which makes it possible to evaluate it as a promising antimutagenic agent.
About the authors
Yu. A. Sarycheva
Orenburg State Medical University
Author for correspondence.
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
Russian FederationA. A. Tokareva
Orenburg State Medical University
Email: fake@neicon.ru
assistant of the Department of Pathological Physiology,
Orenburg
Russian FederationT. V. Panfilova
Orenburg State Medical University
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
Russian FederationA. D. Zheleznova
Orenburg State Medical University
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
Russian FederationB. A. Frolov
Orenburg State Medical University
Email: K_pathphys@orgma.ru
MD, professor, Head of the Department of Pathological Physiology,
Orenburg
Russian FederationReferences
- Курмуков И. А. Лекарственное поражение печени при лечении онкогематологических заболеваний. Клиническая онкогематология 2010,3(1), 60–66.
- Фролов Б. А., Калинина О. В., Кириллова А. В., Штиль А. А. Преодоление гепатотоксичности метотрексата. Клиническая онкогематология 2013, 6(1), 1–10.
- Frolov B. A., Kirillova A. V. Miliacine as a membranoprotector. The protective miliacine action under detergent-induced immunosupression. Russian Journal of Allergy 2011,4(1), 402–403.
