TRITERPENOID MILIACINE AS A PROTECTOR OF CHROMOSOMAL ABERRATIONS INDUCED BY CYCLOPHOSPHAMIDE IN MICE BONE MARROW CELLS
- 作者: Sarycheva Y.1, Tokareva A.1, Panfilova T.1, Zheleznova A.1, Frolov B.1
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隶属关系:
- Orenburg State Medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 527-529
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120291
- DOI: https://doi.org/10.31857/S102872210006953-3
- ID: 120291
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全文:
详细
A study of the antimutagenic eff ect of miliacin, assessed by indicators of chromosomal aberrations in mice bone marrow cells under the conditions of cyclophosphamide use, was carried out. Triterpenoid protected the mutagenic action of cyclophosphamide by the signifi cant reduction of the relative content of aberrant cells and the number of aberrations, which makes it possible to evaluate it as a promising antimutagenic agent.
作者简介
Yu. Sarycheva
Orenburg State Medical University
编辑信件的主要联系方式.
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
俄罗斯联邦A. Tokareva
Orenburg State Medical University
Email: fake@neicon.ru
assistant of the Department of Pathological Physiology,
Orenburg
俄罗斯联邦T. Panfilova
Orenburg State Medical University
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
俄罗斯联邦A. Zheleznova
Orenburg State Medical University
Email: fake@neicon.ru
associate professor of the Department of Pathological Physiology,
Orenburg
俄罗斯联邦B. Frolov
Orenburg State Medical University
Email: K_pathphys@orgma.ru
MD, professor, Head of the Department of Pathological Physiology,
Orenburg
俄罗斯联邦参考
- Курмуков И. А. Лекарственное поражение печени при лечении онкогематологических заболеваний. Клиническая онкогематология 2010,3(1), 60–66.
- Фролов Б. А., Калинина О. В., Кириллова А. В., Штиль А. А. Преодоление гепатотоксичности метотрексата. Клиническая онкогематология 2013, 6(1), 1–10.
- Frolov B. A., Kirillova A. V. Miliacine as a membranoprotector. The protective miliacine action under detergent-induced immunosupression. Russian Journal of Allergy 2011,4(1), 402–403.
