CAFFEINE-MODULATED IMMUNE CELLS EFFECT ON BEHAVIOR PATTERNS IN DEPRESSIVE-LIKE ANIMALS
- Authors: Markova E.V.1,2, Knyazheva M.A.1, Amstislavskaya T.G.3
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Affiliations:
- Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology
- Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Pedagogical University»
- Federal State Budgetary Scientifi c Research Institute of the Physiology and Fundamental Medicine
- Issue: Vol 22, No 2-1 (2019)
- Pages: 397-399
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120134
- DOI: https://doi.org/10.31857/S102872210006909-4
- ID: 120134
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Abstract
Disruption of neuroimmune interaction is an essential link in the pathogenesis of behavioral disorders.The unidirectional influence of most psychoactive substances on nervous and immune systems makes it possible to consider immune cells as model objects for influencing the intersystem functional relationship.The purpose of this work was to study the eff ect of the caff eine ‒ modulated immune cells transplantation on the behavioral patterns in depressive-like animals. The results show a corrective depressive-like behavior eff ect, resulting in a decrease in anhedonia, stimulation of behavior in the open field and a significant increase in the time periods of mobility in the forced swimming test registered against the background of changes in the braincytokines content.
About the authors
E. V. Markova
Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology;Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Pedagogical University»
Author for correspondence.
Email: fake@neicon.ru
Doctor of Medical Sciences, Head of the Neuroimmunology laboratory, Chief Researcher;
Professor,
Novosibirsk
Russian FederationM. A. Knyazheva
Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology
Email: fake@neicon.ru
Graduate student of the Neuroimmunology laboratory,
Novosibirsk
Russian FederationT. G. Amstislavskaya
Federal State Budgetary Scientifi c Research Institute of the Physiology and Fundamental Medicine
Email: fake@neicon.ru
Doctor of Biological Sciences, Head of the Translational Biopsychiatry Laboratory, Chief Researcher,
Novosibirsk
Russian FederationReferences
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