CAFFEINE-MODULATED IMMUNE CELLS EFFECT ON BEHAVIOR PATTERNS IN DEPRESSIVE-LIKE ANIMALS
- 作者: Markova E.1,2, Knyazheva M.1, Amstislavskaya T.3
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隶属关系:
- Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology
- Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Pedagogical University»
- Federal State Budgetary Scientifi c Research Institute of the Physiology and Fundamental Medicine
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 397-399
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120134
- DOI: https://doi.org/10.31857/S102872210006909-4
- ID: 120134
如何引用文章
全文:
详细
Disruption of neuroimmune interaction is an essential link in the pathogenesis of behavioral disorders.The unidirectional influence of most psychoactive substances on nervous and immune systems makes it possible to consider immune cells as model objects for influencing the intersystem functional relationship.The purpose of this work was to study the eff ect of the caff eine ‒ modulated immune cells transplantation on the behavioral patterns in depressive-like animals. The results show a corrective depressive-like behavior eff ect, resulting in a decrease in anhedonia, stimulation of behavior in the open field and a significant increase in the time periods of mobility in the forced swimming test registered against the background of changes in the braincytokines content.
作者简介
E. Markova
Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology;Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Pedagogical University»
编辑信件的主要联系方式.
Email: fake@neicon.ru
Doctor of Medical Sciences, Head of the Neuroimmunology laboratory, Chief Researcher;
Professor,
Novosibirsk
俄罗斯联邦M. Knyazheva
Federal State Budgetary Scientific Research Institute of the Fundamental and Clinical Immunology
Email: fake@neicon.ru
Graduate student of the Neuroimmunology laboratory,
Novosibirsk
俄罗斯联邦T. Amstislavskaya
Federal State Budgetary Scientifi c Research Institute of the Physiology and Fundamental Medicine
Email: fake@neicon.ru
Doctor of Biological Sciences, Head of the Translational Biopsychiatry Laboratory, Chief Researcher,
Novosibirsk
俄罗斯联邦参考
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- Idova G. V., Markova E. V., Gevorgyan M. M., Al’perina E. L., Zhanaeva S. Ya. Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress. Bull. Exp. Biol. Med. 2018, 164 (5), 645–649.
- Маркова Е. В. Иммунная система и высшая нервная деятельность. Механизмы нейроиммунных взаимодействий в реализации и регуляции поведенческих реакций. Saarbruken, 2012.
- Маркова Е. В., Княжева М. А., Козлов В. А. Клеточные механизмы нейроиммунных взаимодействий в регуляции ориентировочно-ис сле дова тельского поведения. Сибирский вестник психиатрии и наркологии. 2013., 1 (76), 49–52.
- Маркова Е. В., Княжева М. А., Шушпанова Т. В., Козлов В. А. Стимуляция пассивного поведения трансплантацией иммунокомпетентных клеток, экстракорпорально обработанных психоактивным препаратом Сибирский вестник психиатрии и наркологии. 2015, 4 (89), 5–9.
