Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia
- 作者: Sokolova K..1,2, Belousova A..1, Gette I..1,2, Danilova I..1,2, Abidov M..2
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隶属关系:
- Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B.N. Yeltsin
- 期: 卷 21, 编号 3 (2018)
- 页面: 439-443
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119936
- DOI: https://doi.org/10.31857/S102872210002424-1
- ID: 119936
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Restoring of insulin-synthesizing cell pool by means of macrophage activity modulation can be a promising direction in the treatment of diabetes mellitus. Modeling of type 2 diabetes mellitus in rats (110 mg / kg of nicotinamide and 65 mg / kg of streptozotocin) caused a spontaneous compensatory increase in the number of extra islet insulin-producing cells up to 30 days, followed by a decrease in the number of these cells by 60 days without enhancing their functional activity. Modulation of macrophage activity with the administration of aminophthalhydrazide (2 mg / kg, 20 injections) to diabetic rats was accompanied by an increase in the number of the extra islet insulin-producing cells, the accumulation of insulin in all the studied groups of these cells, and a reduction in hyperglycemia.
作者简介
K. Sokolova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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A. Belousova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
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I. Gette
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
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I. Danilova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
俄罗斯联邦
M. Abidov
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: noemail@neicon.ru
俄罗斯联邦
参考
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