CD4+ T-LYMPHOCYTE FUNCTION IS VIOLATED IN HIV-INFECTED PATIENTS WITH DISCORDANT RESPONSE TO ANTIRETROVIRAL THERAPY
- Authors: Korolevskaya L.B.1, Saidakova E.V.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 329-331
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119896
- DOI: https://doi.org/10.31857/S102872210006617-3
- ID: 119896
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Abstract
In HIV-infected patients with a discordant response to antiretroviral therapy, CD4+ T-cell proliferative capacity, ability to synthesize IL-2, and resistance to apoptosis were accessed. It was shown that in those subjects, CD4+ T-cells are characterized by a decreased mitotic activity and IL-2 production; and an increased rate of programmed death. Disorders found could be the basis for the ineff ective CD4+ Tcell counts restoration in patients with a discordant response to the treatment.
About the authors
L. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: bioqueen@mail.ru
PhD, research scientist of the Laboratory of Ecological Immunology,
Perm
Russian FederationE. V. Saidakova
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, junior research scientist of the Laboratory of Ecological Immunology,
Perm
Russian FederationReferences
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