CD4+ T-LYMPHOCYTE FUNCTION IS VIOLATED IN HIV-INFECTED PATIENTS WITH DISCORDANT RESPONSE TO ANTIRETROVIRAL THERAPY
- 作者: Korolevskaya L.B.1, Saidakova E.V.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 329-331
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119896
- DOI: https://doi.org/10.31857/S102872210006617-3
- ID: 119896
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详细
In HIV-infected patients with a discordant response to antiretroviral therapy, CD4+ T-cell proliferative capacity, ability to synthesize IL-2, and resistance to apoptosis were accessed. It was shown that in those subjects, CD4+ T-cells are characterized by a decreased mitotic activity and IL-2 production; and an increased rate of programmed death. Disorders found could be the basis for the ineff ective CD4+ Tcell counts restoration in patients with a discordant response to the treatment.
作者简介
L. Korolevskaya
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: bioqueen@mail.ru
PhD, research scientist of the Laboratory of Ecological Immunology,
Perm
俄罗斯联邦E. Saidakova
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, junior research scientist of the Laboratory of Ecological Immunology,
Perm
俄罗斯联邦参考
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- Сайдакова Е. В., Шмагель К. В., Королевская Л. Б., Шмагель Н. Г., Гуляева Н. И., Фрейнд Г. Г., Южанинова С. В., Черешнев В. А. Пролиферация CD4+ Т-лим фо цитов пр развитии дискордантного ответа иммунной системы на антиретровирусную терапию у ВИЧ-ин фи ци ро ван ных больных. Цитология, 2018, 60(12), 1029–1036.
- Bocharov G., Luzyanina T., Cupovic J., Ludewig B. Asymmetry of cell division in CFSE-based lymphocyte proliferation analysis. Front. Immunol. 2013, 4, 264.
- Hansjee N., Kaufmann G. R., Strub C., Weber R., Battegay M., Erb P., and the Swiss HIV Cohort Study. Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes. J. Acquir. Immune. Defic. Syndr, 2004, 36, 671–677.
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