INDUCTION OF ANTIGENIC DETERMINANTS FOR REGULATORY RHEUMATHOID FACTOR ON FC FRAGMENTS OF HUMAN IgG

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Abstract

Recently, we detected a rheumatoid factor, called regulatory, whose production prevents development and causes a remission of experimentally-induced autoimmune diseases. The aim of this study was to elucidate the mechanism of induction of antigenic determinants for regulatory rheumatoid factor onIgG and Fc fragments of human IgG. It was found out that antigenic determinants for regulatory rheumatoid factor are formed in the hinge region of IgG uponthe reduction of sulfhydryl bondby treatment of the IgG molecule with polyethylene glycol or dithiothreitol. In response to the immunization of rats with native human IgG, the production of antibodies similar in specificity to human regulatory rheumatoid factor occurs, suggests that there is an endogenous mechanism for the formation of neoantigenic determinants for regulatory rheumatoid factor

About the authors

A. Yu. Sidorov

Udmurt State University

Author for correspondence.
Russian Federation

E. Yu. Stolyarova

Udmurt State University

Russian Federation

T. V. Khramova

Udmurt State University

Russian Federation

A. S. Terentiev

Udmurt State University

Russian Federation

M. P. Irina

Udmurt State University

Russian Federation

A. M. Gorbushina

Udmurt State University

Russian Federation

L. A. Paderina

Udmurt State University

Russian Federation

References

  1. BedulevaL., MenshikovI., StolyarovaE., FominaK., LobanovaO., et al., Rheumatoid factor in idiotypic regulation of autoimmunity, Int. J. Rheum Dis. 2015, 18, 408-420.
  2. Sidorov A., Beduleva L., Menshikov I., Terentiev A., Stolyarova E. et al. Fc fragments of immunoglobulin G are an inductor of regulatory rheumatoid factor and a promising therapeutic agent for rheumatic diseases. Int. J. Biol. Macromolec. 2017, 95, 938-945.

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Copyright (c) 2017 Sidorov A.Y., Stolyarova E.Y., Khramova T.V., Terentiev A.S., Irina M.P., Gorbushina A.M., Paderina L.A.

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