ANALYSIS OF PHAGOCYTIC ACTIVITY OF NEUTROPHILS DURING ATHEROSCLEROSIS
- Authors: Kilinа O.Y.1, Dutova S.V.1, Saranchina Y.V.1, Matrosova T.A.1, Pol’shcha N.G.1, Kulakova T.S.1, Chanarin N.V.1, Shandakov P.I.2
-
Affiliations:
- Khakass state University named after N. F. Katanov
- Republican clinical hospital named after G. YA. Remishevskaya
- Issue: Vol 22, No 2-1 (2019)
- Pages: 299-301
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119807
- DOI: https://doi.org/10.31857/S102872210006607-2
- ID: 119807
Cite item
Full Text
Abstract
The article presents the results of a comparative analysis of phagocytic activity of neutrophils, isolated from explants of atherosclerotic plaques obtained during endarterectomy in patients with atherosclerosis of the brachiocephalic and femoral arteries and peripheral blood neutrophils of the same patients. Phagocytic activity of neutrophils in atherosclerotic plaques was found to be statistically significantly reduced. We assume that the depletion of the functional ability of neutrophils in the composition of atherosclerotic plaques is associated with chronic inflammation in the intima of vessels in atherosclerosis.
About the authors
O. Yu. Kilinа
Khakass state University named after N. F. Katanov
Author for correspondence.
doctor of medical Sciences, Director of Medical-psychological-social Institute, Professor of the Department of internal diseases,
Abakan
Russian FederationS. V. Dutova
Khakass state University named after N. F. Katanov
doctor of science, associate Professor, acting head of the Department of fundamental medicine and hygiene of Medical, psychological and social Institute,
Abakan
Russian FederationYu. V. Saranchina
Khakass state University named after N. F. Katanov
PhD, associate Professor of the Department of fundamental medicine and hygiene,
Abakan
Russian FederationT. A. Matrosova
Khakass state University named after N. F. Katanov
student of Medical-psychological-social Institute,
Abakan
Russian FederationN. G. Pol’shcha
Khakass state University named after N. F. Katanov
associate Professor in the Department of internal diseases,
Abakan
Russian FederationT. S. Kulakova
Khakass state University named after N. F. Katanov
post-graduate student of the Department of General professional disciplines,
Abakan
Russian FederationN. V. Chanarin
Khakass state University named after N. F. Katanov
PhD, associate Professor of the Department of General professional disciplines,
Abakan
Russian FederationP. I. Shandakov
Republican clinical hospital named after G. YA. Remishevskaya
PhD, head of the Department of vascular surgery,
Abakan
Russian FederationReferences
- Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol, 2008, 8, 802–815.
- Xue-Mei L, Jie Ch, Dai Xuan, Xiao-Xing L, ChunLin H, Yu-Jie L. Changes in CD4+CD25+ Tregs in the pathogenesis of atherosclerosis in ApoE-/- mice. Exp Biol Med (Maywood), 2017, 242(9), 918–925.
- Sivalingam Z., Larsen S. B., Grove E. L., Hvas A. M., Kristensen S.D., Magnusson N. E. Neutrophil gelatinase-associated lipocalin as a risk marker in cardiovascular disease(Review). Clinical Chemistry and Laboratory Medicine, 2017, 56(1), 5–18.
- Pertiwi K.R., van der Wal A.C., Pabittei D.R., Mackaaij C., van Leeuwen M.B., Li X, de Boer O. J. Neutrophil кxtracellular traps participate in all different types of thrombotic and haemorrhagic complications of coronary atherosclerosis. Thrombosis and Haemostasis, 2018, 118(6), 1078–87. 5. Hoyer F. F., Nahrendorf M. Neutrophil contributions to ischaemic heart disease. Eur Heart J, 2017, 3, 465–472.
Supplementary files
