INFLUENCY OF INFLUENCES OF REGULATORY PEPTIDES AND RECOMBINANT IFNα ON THE PHENOTYPE OF THE SUBSET CD66b+CD33+CD16+CD11b+NEUTROFIL GRANULOCYTES IN VITRO

I. V. Nesterova; Нестерова И. В.; G. A. Chudilova; Чудилова Г. А.; S. V. Kovaleva; Ковалева С. В.; L. V. Lomtatidze; Ломтатидзе Л. В.; T. V. Rusinova; Русинова Т. В.; V. A. Tarakanov; Тараканов В. А.; N. K. Barova; Барова Н. К.; V. N. Pavlenko; Павленко В. Н.

doi:10.31857/S102872210006645-4

INFLUENCY OF INFLUENCES OF REGULATORY PEPTIDES AND RECOMBINANT IFNα ON THE PHENOTYPE OF THE SUBSET CD66b+CD33+CD16+CD11b+NEUTROFIL GRANULOCYTES IN VITRO

Authors: Nesterova I.V.¹^,2, Chudilova G.A.¹, Kovaleva S.V.¹, Lomtatidze L.V.¹, Rusinova T.V.¹, Tarakanov V.A.¹, Barova N.K.¹, Pavlenko V.N.¹
Affiliations:
1. Kuban State Medical University
2. Peoples’ Friendship University of Russia
Issue: Vol 22, No 2-2 (2019)
Pages: 867-869
Section: ORIGINAL ARTICLES
URL: https://journals.rcsi.science/1028-7221/article/view/119786
DOI: https://doi.org/10.31857/S102872210006645-4
ID: 119786

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Abstract

A model of the bacterial process under the influence of fMLP was reproduced in the in vitro system, which made it possible to reveal the features of the transformation of CD66b⁺CD33⁺CD16⁺CD11b⁺neutrofi l granulocytes (NG). Multidirectional effects of mono-effects of peptides and rIFNα2b on the expression of the studied markers of NG in healthy children were identified. The modulating effect of rIFNα2b on the transformed fMLP phenotype of NG is associated with polarization into an anti-inflammatory phenotype.

Keywords

neutrophilic granulocytes, phenotype, subset

About the authors

I. V. Nesterova

Kuban State Medical University;
Peoples’ Friendship University of Russia

Author for correspondence.
Email: inesterova1@yandex.ru

Chief Researcher, Central Research Laboratory;

MD, Professor, Department of Allergology and Immunology,

Russian Federation